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Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

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Vis graf over relationer
Nonsense-mediated mRNA decay (NMD) affects the outcome of alternative splicing by degrading mRNA isoforms with premature termination codons. Splicing regulators constitute important NMD targets; however, the extent to which loss of NMD causes extensive deregulation of alternative splicing has not previously been assayed in a global, unbiased manner. Here, we combine mouse genetics and RNA-seq to provide the first in vivo analysis of the global impact of NMD on splicing patterns in two primary mouse tissues ablated for the NMD factor UPF2.
OriginalsprogEngelsk
TidsskriftGenome Biology (Online Edition)
Vol/bind13
Udgave nummer5
Sider (fra-til)R35
ISSN1474-760X
DOI
StatusUdgivet - 2012

ID: 36840326