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Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma

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Harvard

Lauenborg, B, Christensen, L, Ralfkiaer, U, Kopp, KL, Jønson, L, Dabelsteen, S, Bonefeld, CM, Geisler, C, Gjerdrum, LMR, Zhang, Q, Wasik, MA, Ralfkiaer, E, Ødum, N & Woetmann, A 2015, 'Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma' Oncotarget, bind 6, nr. 17, s. 15235-49.

APA

Lauenborg, B., Christensen, L., Ralfkiaer, U., Kopp, K. L., Jønson, L., Dabelsteen, S., ... Woetmann, A. (2015). Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma. Oncotarget, 6(17), 15235-49.

CBE

Lauenborg B, Christensen L, Ralfkiaer U, Kopp KL, Jønson L, Dabelsteen S, Bonefeld CM, Geisler C, Gjerdrum LMR, Zhang Q, Wasik MA, Ralfkiaer E, Ødum N, Woetmann A. 2015. Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma. Oncotarget. 6(17):15235-49.

MLA

Vancouver

Author

Lauenborg, Britt ; Christensen, Louise ; Ralfkiaer, Ulrik ; Kopp, Katharina L ; Jønson, Lars ; Dabelsteen, Sally ; Bonefeld, Charlotte M ; Geisler, Carsten ; Gjerdrum, Lise Mette R ; Zhang, Qian ; Wasik, Mariusz A ; Ralfkiaer, Elisabeth ; Ødum, Niels ; Woetmann, Anders. / Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma. I: Oncotarget. 2015 ; Bind 6, Nr. 17. s. 15235-49.

Bibtex

@article{73670533a21841c7af57f0ba9aa70c50,
title = "Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma",
abstract = "Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK3/STAT5 pathway. Importantly, via TNF receptor 2, LTα functions as an autocrine factor by stimulating expression of IL-6 in the malignant cells. LTα and IL-6, together with VEGF promote angiogenesis by inducing endothelial cell sprouting and tube formation. Thus, we propose that LTα plays a role in malignant angiogenesis and disease progression in CTCL and may serve as a therapeutic target in this disease.",
author = "Britt Lauenborg and Louise Christensen and Ulrik Ralfkiaer and Kopp, {Katharina L} and Lars J{\o}nson and Sally Dabelsteen and Bonefeld, {Charlotte M} and Carsten Geisler and Gjerdrum, {Lise Mette R} and Qian Zhang and Wasik, {Mariusz A} and Elisabeth Ralfkiaer and Niels {\O}dum and Anders Woetmann",
note = "Lauenborg B1, Christensen L1, Ralfkiaer U2, Kopp KL1, J{\o}nson L3, Dabelsteen S4, Bonefeld CM1, Geisler C1, Gjerdrum LM5, Zhang Q6, Wasik MA6, Ralfkiaer E7, {\O}dum N1, Woetmann A1. Author information 1Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. 2Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark. 3Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark. 4Department of Oral Medicine and Pathology, School of Dentistry, University of Copenhagen, Copenhagen, Denmark. 5Department of Pathology, Roskilde Hospital, Roskilde, Denmark. 6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. 7Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.",
year = "2015",
month = "6",
day = "20",
language = "English",
volume = "6",
pages = "15235--49",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "17",

}

RIS

TY - JOUR

T1 - Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma

AU - Lauenborg, Britt

AU - Christensen, Louise

AU - Ralfkiaer, Ulrik

AU - Kopp, Katharina L

AU - Jønson, Lars

AU - Dabelsteen, Sally

AU - Bonefeld, Charlotte M

AU - Geisler, Carsten

AU - Gjerdrum, Lise Mette R

AU - Zhang, Qian

AU - Wasik, Mariusz A

AU - Ralfkiaer, Elisabeth

AU - Ødum, Niels

AU - Woetmann, Anders

N1 - Lauenborg B1, Christensen L1, Ralfkiaer U2, Kopp KL1, Jønson L3, Dabelsteen S4, Bonefeld CM1, Geisler C1, Gjerdrum LM5, Zhang Q6, Wasik MA6, Ralfkiaer E7, Ødum N1, Woetmann A1. Author information 1Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. 2Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark. 3Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark. 4Department of Oral Medicine and Pathology, School of Dentistry, University of Copenhagen, Copenhagen, Denmark. 5Department of Pathology, Roskilde Hospital, Roskilde, Denmark. 6Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. 7Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.

PY - 2015/6/20

Y1 - 2015/6/20

N2 - Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK3/STAT5 pathway. Importantly, via TNF receptor 2, LTα functions as an autocrine factor by stimulating expression of IL-6 in the malignant cells. LTα and IL-6, together with VEGF promote angiogenesis by inducing endothelial cell sprouting and tube formation. Thus, we propose that LTα plays a role in malignant angiogenesis and disease progression in CTCL and may serve as a therapeutic target in this disease.

AB - Lymphotoxin α (LTα) plays a key role in the formation of lymphatic vasculature and secondary lymphoid structures. Cutaneous T cell lymphoma (CTCL) is the most common primary lymphoma of the skin and in advanced stages, malignant T cells spreads through the lymphatic to regional lymph nodes to internal organs and blood. Yet, little is known about the mechanism of the CTCL dissemination. Here, we show that CTCL cells express LTα in situ and that LTα expression is driven by aberrantly activated JAK3/STAT5 pathway. Importantly, via TNF receptor 2, LTα functions as an autocrine factor by stimulating expression of IL-6 in the malignant cells. LTα and IL-6, together with VEGF promote angiogenesis by inducing endothelial cell sprouting and tube formation. Thus, we propose that LTα plays a role in malignant angiogenesis and disease progression in CTCL and may serve as a therapeutic target in this disease.

M3 - Journal article

VL - 6

SP - 15235

EP - 15249

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 17

ER -

ID: 45731609