Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea

Margherita Di Mauro; Sara El Hoss; Amina Nardo-Marino; Sara Stuart-Smith; John Strouboulis; John S Gibson; David C Rees; John N Brewin

doi:10.1002/ajh.27074

Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea

Margherita Di Mauro
, Sara El Hoss
, Amina Nardo-Marino
, Sara Stuart-Smith
, John Strouboulis
, John S Gibson
, David C Rees
, John N Brewin^*

^*Corresponding author af dette arbejde

Afdeling for Blodsygdomme

12 Citationer (Scopus)

Abstract

Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.

Originalsprog	Engelsk
Tidsskrift	American Journal of Hematology
Vol/bind	98
Udgave nummer	11
Sider (fra-til)	E341-E344
ISSN	0361-8609
DOI	https://doi.org/10.1002/ajh.27074
Status	Udgivet - nov. 2023

Adgang til dokumentet

10.1002/ajh.27074

Andre filer og links

Link to publication in Scopus

Citationsformater

@article{9deeb2fe1b95432b9949a2d00655bd48,

title = "Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea",

abstract = "Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.",

author = "\{Di Mauro\}, Margherita and \{El Hoss\}, Sara and Amina Nardo-Marino and Sara Stuart-Smith and John Strouboulis and Gibson, \{John S\} and Rees, \{David C\} and Brewin, \{John N\}",

note = "{\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = nov,

doi = "10.1002/ajh.27074",

language = "English",

volume = "98",

pages = "E341--E344",

journal = "American Journal of Hematology",

issn = "0361-8609",

publisher = "John Wiley and Sons Inc.",

number = "11",

}

TY - JOUR

T1 - Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea

AU - Di Mauro, Margherita

AU - El Hoss, Sara

AU - Nardo-Marino, Amina

AU - Stuart-Smith, Sara

AU - Strouboulis, John

AU - Gibson, John S

AU - Rees, David C

AU - Brewin, John N

PY - 2023/11

Y1 - 2023/11

N2 - Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.

AB - Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.

UR - https://www.scopus.com/pages/publications/85169676341

U2 - 10.1002/ajh.27074

DO - 10.1002/ajh.27074

M3 - Letter

C2 - 37646569

SN - 0361-8609

VL - 98

SP - E341-E344

JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 11

ER -

Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater