Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea

Margherita Di Mauro, Sara El Hoss, Amina Nardo-Marino, Sara Stuart-Smith, John Strouboulis, John S Gibson, David C Rees, John N Brewin*

*Corresponding author af dette arbejde

Abstract

Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Hematology
Vol/bind98
Udgave nummer11
Sider (fra-til)E341-E344
ISSN0361-8609
DOI
StatusUdgivet - nov. 2023

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