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Male origin microchimerism and ovarian cancer

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Harvard

Hallum, S, Jakobsen, MA, Gerds, TA, Pinborg, A, Tjønneland, A & Kamper-Jørgensen, M 2021, 'Male origin microchimerism and ovarian cancer', International Journal of Epidemiology, bind 50, nr. 1, s. 87-94. https://doi.org/10.1093/ije/dyaa019

APA

Hallum, S., Jakobsen, M. A., Gerds, T. A., Pinborg, A., Tjønneland, A., & Kamper-Jørgensen, M. (2021). Male origin microchimerism and ovarian cancer. International Journal of Epidemiology, 50(1), 87-94. https://doi.org/10.1093/ije/dyaa019

CBE

Hallum S, Jakobsen MA, Gerds TA, Pinborg A, Tjønneland A, Kamper-Jørgensen M. 2021. Male origin microchimerism and ovarian cancer. International Journal of Epidemiology. 50(1):87-94. https://doi.org/10.1093/ije/dyaa019

MLA

Vancouver

Hallum S, Jakobsen MA, Gerds TA, Pinborg A, Tjønneland A, Kamper-Jørgensen M. Male origin microchimerism and ovarian cancer. International Journal of Epidemiology. 2021 feb;50(1):87-94. https://doi.org/10.1093/ije/dyaa019

Author

Hallum, Sara ; Jakobsen, Marianne Antonius ; Gerds, Thomas Alexander ; Pinborg, Anja ; Tjønneland, Anne ; Kamper-Jørgensen, Mads. / Male origin microchimerism and ovarian cancer. I: International Journal of Epidemiology. 2021 ; Bind 50, Nr. 1. s. 87-94.

Bibtex

@article{f17fc98c60754fbbabedef420fb5e44b,
title = "Male origin microchimerism and ovarian cancer",
abstract = "BACKGROUND: Reduced risk of ovarian cancer is commonly ascribed to reduced exposure to endogenous hormones during pregnancy, using oral contraceptives or not using hormone replacement therapy. However, exposure to hormones alone account for less than half of all cases. Many women carry small amounts of male cells-known as male origin microchimerism-in their circulation and remarkable impacts of these cells on women's health are being published. Here, we pursue the possibility that male origin microchimerism has a role in reducing ovarian cancer risk.METHODS: We conducted a prospective case-cohort study using blood samples and questionnaire data from 700 women participating in the Danish Diet, Cancer, and Health cohort. Blood samples were analysed for Y chromosome presence as a marker of male microchimerism. We evaluated the association between male microchimerism and ovarian cancer, using weighted Cox regression models reporting hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).RESULTS: Male microchimerism was detected in 46% of cases and 65.9% of controls. Women testing positive for male microchimerism had a reduced hazard rate of ovarian cancer compared with women testing negative (HR = 0.44, 95% CI: 0.29-0.68). We found no evidence of interaction with measures of hormonal exposures (P = 0.50).CONCLUSIONS: For the first time we report that women who test positive for male microchimerism in their circulation have reduced rates of ovarian cancer compared with women who test negative. Although the underlying mechanisms are presently unknown, we believe male microchimerism is potent in preventing ovarian cancer.",
keywords = "epidemiology, microchimerism, ovarian cancer, Pregnancy",
author = "Sara Hallum and Jakobsen, {Marianne Antonius} and Gerds, {Thomas Alexander} and Anja Pinborg and Anne Tj{\o}nneland and Mads Kamper-J{\o}rgensen",
note = "{\textcopyright} The Author(s) 2020; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.",
year = "2021",
month = feb,
doi = "10.1093/ije/dyaa019",
language = "English",
volume = "50",
pages = "87--94",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Male origin microchimerism and ovarian cancer

AU - Hallum, Sara

AU - Jakobsen, Marianne Antonius

AU - Gerds, Thomas Alexander

AU - Pinborg, Anja

AU - Tjønneland, Anne

AU - Kamper-Jørgensen, Mads

N1 - © The Author(s) 2020; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND: Reduced risk of ovarian cancer is commonly ascribed to reduced exposure to endogenous hormones during pregnancy, using oral contraceptives or not using hormone replacement therapy. However, exposure to hormones alone account for less than half of all cases. Many women carry small amounts of male cells-known as male origin microchimerism-in their circulation and remarkable impacts of these cells on women's health are being published. Here, we pursue the possibility that male origin microchimerism has a role in reducing ovarian cancer risk.METHODS: We conducted a prospective case-cohort study using blood samples and questionnaire data from 700 women participating in the Danish Diet, Cancer, and Health cohort. Blood samples were analysed for Y chromosome presence as a marker of male microchimerism. We evaluated the association between male microchimerism and ovarian cancer, using weighted Cox regression models reporting hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).RESULTS: Male microchimerism was detected in 46% of cases and 65.9% of controls. Women testing positive for male microchimerism had a reduced hazard rate of ovarian cancer compared with women testing negative (HR = 0.44, 95% CI: 0.29-0.68). We found no evidence of interaction with measures of hormonal exposures (P = 0.50).CONCLUSIONS: For the first time we report that women who test positive for male microchimerism in their circulation have reduced rates of ovarian cancer compared with women who test negative. Although the underlying mechanisms are presently unknown, we believe male microchimerism is potent in preventing ovarian cancer.

AB - BACKGROUND: Reduced risk of ovarian cancer is commonly ascribed to reduced exposure to endogenous hormones during pregnancy, using oral contraceptives or not using hormone replacement therapy. However, exposure to hormones alone account for less than half of all cases. Many women carry small amounts of male cells-known as male origin microchimerism-in their circulation and remarkable impacts of these cells on women's health are being published. Here, we pursue the possibility that male origin microchimerism has a role in reducing ovarian cancer risk.METHODS: We conducted a prospective case-cohort study using blood samples and questionnaire data from 700 women participating in the Danish Diet, Cancer, and Health cohort. Blood samples were analysed for Y chromosome presence as a marker of male microchimerism. We evaluated the association between male microchimerism and ovarian cancer, using weighted Cox regression models reporting hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).RESULTS: Male microchimerism was detected in 46% of cases and 65.9% of controls. Women testing positive for male microchimerism had a reduced hazard rate of ovarian cancer compared with women testing negative (HR = 0.44, 95% CI: 0.29-0.68). We found no evidence of interaction with measures of hormonal exposures (P = 0.50).CONCLUSIONS: For the first time we report that women who test positive for male microchimerism in their circulation have reduced rates of ovarian cancer compared with women who test negative. Although the underlying mechanisms are presently unknown, we believe male microchimerism is potent in preventing ovarian cancer.

KW - epidemiology

KW - microchimerism

KW - ovarian cancer

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85102657971&partnerID=8YFLogxK

U2 - 10.1093/ije/dyaa019

DO - 10.1093/ije/dyaa019

M3 - Journal article

C2 - 32065627

VL - 50

SP - 87

EP - 94

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 1

ER -

ID: 62292496