Major drawbacks and additional benefits of agonist trigger-not ovarian hyperstimulation syndrome related

Bruce S Shapiro, Claus Yding Andersen

    24 Citationer (Scopus)

    Abstract

    The GnRH agonist trigger alters traditional IVF paradigms when compared with hCG-only triggers. The agonist trigger induces rapid luteolysis and therefore separates the oocyte maturation aspect of LH from the luteal support previously afforded by lingering hCG. This might allow customized and more optimal luteal support. The agonist trigger option also allows continued stimulation and subsequent trigger of high responders with reasonable safety, potentially leading to retrievals of larger cohorts of mature oocytes. It may also reduce the number of retrievals needed to achieve a large family. The agonist trigger might alter other paradigms as well, such as making oocyte donation more efficient per stimulation by virtually eliminating follicular-phase cycle cancellation, coasting, and premature triggering. There are both corresponding potential benefits and drawbacks of using the agonist trigger and the shifting paradigms it allows.

    OriginalsprogEngelsk
    TidsskriftFertility and Sterility
    Vol/bind103
    Udgave nummer4
    Sider (fra-til)874-78
    ISSN0015-0282
    DOI
    StatusUdgivet - 20 feb. 2015

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'Major drawbacks and additional benefits of agonist trigger-not ovarian hyperstimulation syndrome related'. Sammen danner de et unikt fingeraftryk.

    Citationsformater