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Magnetic resonance imaging of the bone marrow following treatment with recombinant human erythropoietin in patients with end-stage renal disease.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  • K E Jensen
  • D Stenver
  • M Jensen
  • P G Sørensen
  • H Karle
  • C Thomsen
  • O Henriksen
  • B Nielsen
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We used magnetic resonance imaging (MRI) to study vertebral bone marrow in hemodialysis patients during treatment with recombinant human erythropoietin (rHuEPO). We found changes in T1 relaxation times and image contrast within 14 days after starting treatment, before any response was seen in the hemoglobin concentration in peripheral blood. The increase in T1 relaxation times, together with earlier reported changes observed with localized magnetic resonance spectroscopy, indicate an alteration in cellular composition of the hemopoietic bone marrow with an increase in the amount of hemopoietic active tissue. MRI may be a useful, non-invasive way of evaluating bone marrow response to different modes of rHuEPO administration and dosage.
Bidragets oversatte titelMagnetic resonance imaging of the bone marrow following treatment with recombinant human erythropoietin in patients with end-stage renal disease.
OriginalsprogEngelsk
TidsskriftInternational Journal of Artificial Organs
Vol/bind13
Udgave nummer8
Sider (fra-til)477-481
Antal sider5
ISSN0391-3988
StatusUdgivet - 1990

ID: 32490050