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Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163.

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Møller, HJ, K. Moestrup, S, Weis, NM, Wejse, C, Nielsen, H, Stenvang Pedersen, S, Attermann, J, Nexø, E & Kronborg, G 2006, 'Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163.' Critical Care Medicine, bind 34, nr. 10, s. 2561-6. https://doi.org/10.1097/01.CCM.0000239120.32490.AB

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Møller, Holger Jon ; K. Moestrup, Søren ; Weis, Nina Margrethe ; Wejse, Christian ; Nielsen, Henrik ; Stenvang Pedersen, Svend ; Attermann, Jørn ; Nexø, Ebba ; Kronborg, Gitte. / Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163. I: Critical Care Medicine. 2006 ; Bind 34, Nr. 10. s. 2561-6.

Bibtex

@article{1ceae8bf977447088ef23a52eeff2c44,
title = "Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163.",
abstract = "OBJECTIVE: Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia. DESIGN: Observational cohort study. SETTING: Five university hospitals in Denmark. PATIENTS: A total of 133 patients with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls. INTERVENTIONS: Samples were collected for biochemical analyses at the time of first positive blood culture. MEASUREMENTS AND MAIN RESULTS: sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25-75 percentiles], 4.6 mg/L [2.8-8.9]) compared with healthy controls (2.7 mg/L [2.1-3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p = .0014; mechanical ventilation, p = .0019). Significantly lower levels of sCD163, ferritin, transcobalamin, and suPAR (but not C-reactive protein) were measured in patients > or =75 yrs. In patients <75 yrs, all macrophage markers were increased in patients who died from their infection compared with survivors, whereas no change was observed in any of the markers in the very old age. At cutoff levels of 9.5 mg/L (sCD163) and 1650 nmol/L (C-reactive protein), the relative risk for fatal outcome in patients <75 yrs was 10.1 (95{\%} confidence interval 3.4-31.0) and 7.0 (95{\%} confidence interval 2.4-21.6) for sCD163 and C-reactive protein, respectively. In a multivariate logistic regression model for patients <75 yrs, ferritin, transcobalamin, neopterin, and suPAR contained no significant information on the probability of survival when sCD163 and CRP were known (p = .25). CONCLUSIONS: Macrophage marker response in pneumococcal bacteremia was compromised in old age. In patients <75 yrs old, sCD163 was superior to other markers, including C-reactive protein, in predicting fatal disease outcome.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Bacteremia, Biological Markers, Case-Control Studies, Female, Humans, Logistic Models, Macrophage Activation, Male, Middle Aged, Multivariate Analysis, Pneumococcal Infections, Prognosis, Receptors, Cell Surface, Sensitivity and Specificity, Streptococcus pneumoniae, Survival Analysis",
author = "M{\o}ller, {Holger Jon} and {K. Moestrup}, S{\o}ren and Weis, {Nina Margrethe} and Christian Wejse and Henrik Nielsen and {Stenvang Pedersen}, Svend and J{\o}rn Attermann and Ebba Nex{\o} and Gitte Kronborg",
year = "2006",
doi = "10.1097/01.CCM.0000239120.32490.AB",
language = "English",
volume = "34",
pages = "2561--6",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams & Wilkins",
number = "10",

}

RIS

TY - JOUR

T1 - Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163.

AU - Møller, Holger Jon

AU - K. Moestrup, Søren

AU - Weis, Nina Margrethe

AU - Wejse, Christian

AU - Nielsen, Henrik

AU - Stenvang Pedersen, Svend

AU - Attermann, Jørn

AU - Nexø, Ebba

AU - Kronborg, Gitte

PY - 2006

Y1 - 2006

N2 - OBJECTIVE: Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia. DESIGN: Observational cohort study. SETTING: Five university hospitals in Denmark. PATIENTS: A total of 133 patients with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls. INTERVENTIONS: Samples were collected for biochemical analyses at the time of first positive blood culture. MEASUREMENTS AND MAIN RESULTS: sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25-75 percentiles], 4.6 mg/L [2.8-8.9]) compared with healthy controls (2.7 mg/L [2.1-3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p = .0014; mechanical ventilation, p = .0019). Significantly lower levels of sCD163, ferritin, transcobalamin, and suPAR (but not C-reactive protein) were measured in patients > or =75 yrs. In patients <75 yrs, all macrophage markers were increased in patients who died from their infection compared with survivors, whereas no change was observed in any of the markers in the very old age. At cutoff levels of 9.5 mg/L (sCD163) and 1650 nmol/L (C-reactive protein), the relative risk for fatal outcome in patients <75 yrs was 10.1 (95% confidence interval 3.4-31.0) and 7.0 (95% confidence interval 2.4-21.6) for sCD163 and C-reactive protein, respectively. In a multivariate logistic regression model for patients <75 yrs, ferritin, transcobalamin, neopterin, and suPAR contained no significant information on the probability of survival when sCD163 and CRP were known (p = .25). CONCLUSIONS: Macrophage marker response in pneumococcal bacteremia was compromised in old age. In patients <75 yrs old, sCD163 was superior to other markers, including C-reactive protein, in predicting fatal disease outcome.

AB - OBJECTIVE: Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, and soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia. DESIGN: Observational cohort study. SETTING: Five university hospitals in Denmark. PATIENTS: A total of 133 patients with Streptococcus pneumoniae bacteremia (positive blood culture) and 133 age- and gender-matched controls. INTERVENTIONS: Samples were collected for biochemical analyses at the time of first positive blood culture. MEASUREMENTS AND MAIN RESULTS: sCD163 was highly correlated with other macrophage markers and was significantly elevated (median [25-75 percentiles], 4.6 mg/L [2.8-8.9]) compared with healthy controls (2.7 mg/L [2.1-3.3], p < .0001). Increased levels were observed in patients who needed intensive care (hemodialysis, p = .0011; hypotension, p = .0014; mechanical ventilation, p = .0019). Significantly lower levels of sCD163, ferritin, transcobalamin, and suPAR (but not C-reactive protein) were measured in patients > or =75 yrs. In patients <75 yrs, all macrophage markers were increased in patients who died from their infection compared with survivors, whereas no change was observed in any of the markers in the very old age. At cutoff levels of 9.5 mg/L (sCD163) and 1650 nmol/L (C-reactive protein), the relative risk for fatal outcome in patients <75 yrs was 10.1 (95% confidence interval 3.4-31.0) and 7.0 (95% confidence interval 2.4-21.6) for sCD163 and C-reactive protein, respectively. In a multivariate logistic regression model for patients <75 yrs, ferritin, transcobalamin, neopterin, and suPAR contained no significant information on the probability of survival when sCD163 and CRP were known (p = .25). CONCLUSIONS: Macrophage marker response in pneumococcal bacteremia was compromised in old age. In patients <75 yrs old, sCD163 was superior to other markers, including C-reactive protein, in predicting fatal disease outcome.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Antigens, CD

KW - Antigens, Differentiation, Myelomonocytic

KW - Bacteremia

KW - Biological Markers

KW - Case-Control Studies

KW - Female

KW - Humans

KW - Logistic Models

KW - Macrophage Activation

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Pneumococcal Infections

KW - Prognosis

KW - Receptors, Cell Surface

KW - Sensitivity and Specificity

KW - Streptococcus pneumoniae

KW - Survival Analysis

U2 - 10.1097/01.CCM.0000239120.32490.AB

DO - 10.1097/01.CCM.0000239120.32490.AB

M3 - Journal article

VL - 34

SP - 2561

EP - 2566

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 10

ER -

ID: 32507315