Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cytomegalovirus-specific CD8+ T-cell responses are associated with arterial blood pressure in people living with HIV

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Making the best of the worst: Care quality during emergency cesarean sections

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. PPARs and the development of Type 1 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. L-serine: a neglected amino acid with a potential therapeutic role in diabetes

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels. L-serine led to a small reduction in body weight accompanied by reduced food and water intake. L-serine had no effect on pancreatic sphingolipids as measured by mass spectrometry. The data thus suggests that L-serine could be used as a therapeutic supplement in the treatment of Type 1 Diabetes and to improve blood glucose homeostasis.

OriginalsprogEngelsk
TidsskriftPLoS One
Vol/bind13
Udgave nummer3
Sider (fra-til)e0194414
ISSN1932-6203
DOI
StatusUdgivet - 2018

ID: 56441185