TY - JOUR
T1 - Lower urinary tract symptoms and bladder control in advanced Parkinson's disease
T2 - effects of deep brain stimulation in the subthalamic nucleus
AU - Winge, Kristian
AU - Nielsen, Kurt Krøyer
AU - Stimpel, Hans
AU - Lokkegaard, Annemette
AU - Jensen, Steen Rusborg
AU - Werdelin, Lene
N1 - (c) 2006 Movement Disorder Society.
PY - 2007/1/15
Y1 - 2007/1/15
N2 - Deep brain stimulation in the subthalamic nucleus (STN) leads to significant improvement in motor function in patients with advanced Parkinson's disease (PD). In this prospective study including 16 patients with PD, we investigated (1) lower urinary tract symptoms (LUTS) by questionnaires International Prostate Symptom Score (IPSS, symptoms only) and Danish Prostate Symptom Score (DanPSS, symptoms and bother of symptoms) and (2) bladder control (assessed by urodynamics) before and after implantation of electrodes in the STN. PD symptoms (Unified Parkinson's Disease Rating Scale score) improved significantly (P < 0.0001), and symptoms of overactive bladder (IPSS) decreased along with the troublesome symptoms of overactive bladder (DanPSS; P < 0.01 for both). Urodynamic parameters before and after implantation of electrodes in the STN, evaluated with and without the stimulation on, did not change significantly.
AB - Deep brain stimulation in the subthalamic nucleus (STN) leads to significant improvement in motor function in patients with advanced Parkinson's disease (PD). In this prospective study including 16 patients with PD, we investigated (1) lower urinary tract symptoms (LUTS) by questionnaires International Prostate Symptom Score (IPSS, symptoms only) and Danish Prostate Symptom Score (DanPSS, symptoms and bother of symptoms) and (2) bladder control (assessed by urodynamics) before and after implantation of electrodes in the STN. PD symptoms (Unified Parkinson's Disease Rating Scale score) improved significantly (P < 0.0001), and symptoms of overactive bladder (IPSS) decreased along with the troublesome symptoms of overactive bladder (DanPSS; P < 0.01 for both). Urodynamic parameters before and after implantation of electrodes in the STN, evaluated with and without the stimulation on, did not change significantly.
KW - Adult
KW - Aged
KW - Deep Brain Stimulation/methods
KW - Electrodes, Implanted
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Parkinson Disease/complications
KW - Prospective Studies
KW - Severity of Illness Index
KW - Subthalamic Nucleus/physiology
KW - Surveys and Questionnaires
KW - Urinary Bladder Neck Obstruction/diagnosis
KW - Urinary Bladder, Overactive/diagnosis
KW - Urodynamics/physiology
KW - Urologic Diseases/diagnosis
U2 - 10.1002/mds.21253
DO - 10.1002/mds.21253
M3 - Journal article
C2 - 17133504
SN - 0885-3185
VL - 22
SP - 220
EP - 225
JO - Movement disorders : official journal of the Movement Disorder Society
JF - Movement disorders : official journal of the Movement Disorder Society
IS - 2
ER -