Lower urinary tract symptoms and bladder control in advanced Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus

Kristian Winge, Kurt Krøyer Nielsen, Hans Stimpel, Annemette Lokkegaard, Steen Rusborg Jensen, Lene Werdelin

70 Citationer (Scopus)

Abstract

Deep brain stimulation in the subthalamic nucleus (STN) leads to significant improvement in motor function in patients with advanced Parkinson's disease (PD). In this prospective study including 16 patients with PD, we investigated (1) lower urinary tract symptoms (LUTS) by questionnaires International Prostate Symptom Score (IPSS, symptoms only) and Danish Prostate Symptom Score (DanPSS, symptoms and bother of symptoms) and (2) bladder control (assessed by urodynamics) before and after implantation of electrodes in the STN. PD symptoms (Unified Parkinson's Disease Rating Scale score) improved significantly (P < 0.0001), and symptoms of overactive bladder (IPSS) decreased along with the troublesome symptoms of overactive bladder (DanPSS; P < 0.01 for both). Urodynamic parameters before and after implantation of electrodes in the STN, evaluated with and without the stimulation on, did not change significantly.

OriginalsprogEngelsk
TidsskriftMovement disorders : official journal of the Movement Disorder Society
Vol/bind22
Udgave nummer2
Sider (fra-til)220-5
Antal sider6
ISSN0885-3185
DOI
StatusUdgivet - 15 jan. 2007

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