Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2

Camilla Heldbjerg Drabe, Ann-Brit Eg Hansen, Line Dahlerup Rasmussen, Olav Ditlevsen Larsen, Axel Møller, Trine H Mogensen, Jannik Helweg-Larsen, Terese L Katzenstein

10 Citationer (Scopus)

Abstrakt

BACKGROUND: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID).

METHODS: A Danish nationwide retrospective clinician-reported survey.

RESULTS: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22-72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered.

CONCLUSIONS: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.

OriginalsprogEngelsk
Artikelnummer1957144
TidsskriftInfectious diseases (London, England)
Vol/bind53
Udgave nummer12
Sider (fra-til)953-958
Antal sider6
ISSN2374-4235
DOI
StatusUdgivet - 11 aug. 2021

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