TY - JOUR
T1 - Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2
AU - Drabe, Camilla Heldbjerg
AU - Hansen, Ann-Brit Eg
AU - Rasmussen, Line Dahlerup
AU - Larsen, Olav Ditlevsen
AU - Møller, Axel
AU - Mogensen, Trine H
AU - Helweg-Larsen, Jannik
AU - Katzenstein, Terese L
PY - 2021/8/11
Y1 - 2021/8/11
N2 - BACKGROUND: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID).METHODS: A Danish nationwide retrospective clinician-reported survey.RESULTS: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22-72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered.CONCLUSIONS: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.
AB - BACKGROUND: Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID).METHODS: A Danish nationwide retrospective clinician-reported survey.RESULTS: Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22-72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered.CONCLUSIONS: The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.
KW - common variable immunodeficiency
KW - COVID-19
KW - inborn errors of immunity
KW - primary immunodeficiency
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85112236286&partnerID=8YFLogxK
U2 - 10.1080/23744235.2021.1957144
DO - 10.1080/23744235.2021.1957144
M3 - Journal article
C2 - 34375571
VL - 53
SP - 953
EP - 958
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 12
M1 - 1957144
ER -