Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

George Fust, Lea Munthe Fog, Zsolt Illes, Gabor Szeplaki, Tihamer Molnar, Gabriella Pusch, Kristof Hirschberg, Robert Szegedi, Zoltan Szeplaki, Zoltan Prohaszka, Mikkel-Ole Skjødt, Peter Garred

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Abstract

ABSTRACT: BACKGROUND: A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to different ligands. Although several papers demonstrated the significance of MBL in ischemic stroke, the role of ficolins has not been examined. METHODS: Sera were obtained within 12 hours after the onset of ischemic stroke (admission samples) and 3-4 days later (follow-up samples) from 65 patients. The control group comprised 100 healthy individuals and 135 patients with significant carotid stenosis (patient controls). The concentrations of ficolin-2 and ficolin-3, initiator molecules of the lectin complement pathway, were measured by ELISA methods. Concentration of C-reactive protein (CRP) was also determined by a particle-enhanced immunturbidimetric assay. RESULTS: Concentrations of both ficolin-2 and ficolin-3 were significantly (p
OriginalsprogEngelsk
TidsskriftJournal of Neuroinflammation
Vol/bind8
Udgave nummer1
Sider (fra-til)185
ISSN1742-2094
DOI
StatusUdgivet - 2011

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