Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Need for better diabetes treatment for improved renal outcome

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Renoprotection with and without blood pressure reduction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Elevated vascular endothelial growth factor in type 1 diabetic patients with diabetic nephropathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Role of patient factors in therapy resistance to antiproteinuric intervention in nondiabetic and diabetic nephropathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Progression of diabetic nephropathy in normotensive type 1 diabetic patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prevalence, type distribution, and risk factors for oral HPV in Danish renal transplant recipients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Fatal pneumococcus meningitis in a child with complement factor ficolin-3 deficiency

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  3. Identification of the novel HLA allele, HLA-C*07:780, identified in a Danish woman

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Complement C4 is a central component of the classical and the lectin pathways of the complement system. The C4 protein exists as two isotypes C4A and C4B encoded by the C4A and C4B genes, both of which are found with varying copy numbers. Deposition of C4 has been implicated in kidney graft rejection, but a relationship between graft survival and serum C4 concentration as well as C4 genetic variation has not been established. We evaluated this using a prospective study design of 676 kidney transplant patients and 211 healthy individuals as controls. Increasing C4 gene copy numbers significantly correlated with the C4 serum concentration in both patients and controls. Patients with less than four total copies of C4 genes transplanted with a deceased donor kidney experienced a superior 5-year graft survival (hazard ratio 0.46, 95% confidence interval: 0.25-0.84). No significant association was observed in patients transplanted with a living donor. Thus, low C4 copy numbers are associated with increased kidney graft survival in patients receiving a kidney from a deceased donor. Hence, the degree of ischemia may influence the clinical impact of complement.
OriginalsprogEngelsk
BogserieKidney International. Supplement
Vol/bind84
Udgave nummer3
Sider (fra-til)562-9
Antal sider8
ISSN0098-6577
DOI
StatusUdgivet - sep. 2013

ID: 39017951