Low bone turnover phenotype in Rett syndrome: Results of biochemical bone marker analysis

Gitte Roende; Janne Petersen; Kirstine Ravn; Kathrine  Fuglsang; Henrik Andersen; Jytte B Nielsen; Karen Brøndum-Nielsen; Jens-Erik B Jensen

doi:10.1038/pr.2013.252

Low bone turnover phenotype in Rett syndrome: Results of biochemical bone marker analysis

Gitte Roende, Janne Petersen, Kirstine Ravn, Kathrine Fuglsang, Henrik Andersen, Jytte B Nielsen, Karen Brøndum-Nielsen, Jens-Erik B Jensen

7 Citationer (Scopus)

Abstract

Background:Patients with Rett syndrome (RTT) are at risk of having low bone mass and low-energy fractures.Methods:We characterised bone metabolism by both bone formation and resorption markers in blood in a RTT population of 61 girls and women and 122 well-matched healthy controls. Levels of N-terminal propeptides of collagen type 1 (P1NP), C-terminal telopeptide cross links (CTX), osteocalcin (OC), and bone specific alkaline phosphatase (B-ALP) were compared between RTT patients and controls in regression models adjusted for body mass index (BMI), vitamin D status, volumetric bone mineral apparent density of the lumbar spine (vBMADspine) and femoral neck (vBMADneck). We examined biochemical bone marker levels overall, and stratified to persons younger than age 25 years or equal to or older than age 25 years.Results:The RTT patients had reduced levels of all biochemical bone markers (p

Originalsprog	Engelsk
Tidsskrift	Pediatric Research
Vol/bind	75
Udgave nummer	4
Sider (fra-til)	551
Antal sider	558
ISSN	0031-3998
DOI	https://doi.org/10.1038/pr.2013.252
Status	Udgivet - 29 jan. 2014

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10.1038/pr.2013.252

Citationsformater

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title = "Low bone turnover phenotype in Rett syndrome: Results of biochemical bone marker analysis",

abstract = "Background:Patients with Rett syndrome (RTT) are at risk of having low bone mass and low-energy fractures.Methods:We characterised bone metabolism by both bone formation and resorption markers in blood in a RTT population of 61 girls and women and 122 well-matched healthy controls. Levels of N-terminal propeptides of collagen type 1 (P1NP), C-terminal telopeptide cross links (CTX), osteocalcin (OC), and bone specific alkaline phosphatase (B-ALP) were compared between RTT patients and controls in regression models adjusted for body mass index (BMI), vitamin D status, volumetric bone mineral apparent density of the lumbar spine (vBMADspine) and femoral neck (vBMADneck). We examined biochemical bone marker levels overall, and stratified to persons younger than age 25 years or equal to or older than age 25 years.Results:The RTT patients had reduced levels of all biochemical bone markers (p",

author = "Gitte Roende and Janne Petersen and Kirstine Ravn and Kathrine Fuglsang and Henrik Andersen and Nielsen, {Jytte B} and Karen Br{\o}ndum-Nielsen and Jensen, {Jens-Erik B}",

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T1 - Low bone turnover phenotype in Rett syndrome

T2 - Results of biochemical bone marker analysis

AU - Roende, Gitte

AU - Petersen, Janne

AU - Ravn, Kirstine

AU - Fuglsang, Kathrine

AU - Andersen, Henrik

AU - Nielsen, Jytte B

AU - Brøndum-Nielsen, Karen

AU - Jensen, Jens-Erik B

PY - 2014/1/29

Y1 - 2014/1/29

N2 - Background:Patients with Rett syndrome (RTT) are at risk of having low bone mass and low-energy fractures.Methods:We characterised bone metabolism by both bone formation and resorption markers in blood in a RTT population of 61 girls and women and 122 well-matched healthy controls. Levels of N-terminal propeptides of collagen type 1 (P1NP), C-terminal telopeptide cross links (CTX), osteocalcin (OC), and bone specific alkaline phosphatase (B-ALP) were compared between RTT patients and controls in regression models adjusted for body mass index (BMI), vitamin D status, volumetric bone mineral apparent density of the lumbar spine (vBMADspine) and femoral neck (vBMADneck). We examined biochemical bone marker levels overall, and stratified to persons younger than age 25 years or equal to or older than age 25 years.Results:The RTT patients had reduced levels of all biochemical bone markers (p

AB - Background:Patients with Rett syndrome (RTT) are at risk of having low bone mass and low-energy fractures.Methods:We characterised bone metabolism by both bone formation and resorption markers in blood in a RTT population of 61 girls and women and 122 well-matched healthy controls. Levels of N-terminal propeptides of collagen type 1 (P1NP), C-terminal telopeptide cross links (CTX), osteocalcin (OC), and bone specific alkaline phosphatase (B-ALP) were compared between RTT patients and controls in regression models adjusted for body mass index (BMI), vitamin D status, volumetric bone mineral apparent density of the lumbar spine (vBMADspine) and femoral neck (vBMADneck). We examined biochemical bone marker levels overall, and stratified to persons younger than age 25 years or equal to or older than age 25 years.Results:The RTT patients had reduced levels of all biochemical bone markers (p

U2 - 10.1038/pr.2013.252

DO - 10.1038/pr.2013.252

M3 - Journal article

C2 - 24375084

SN - 0031-3998

VL - 75

SP - 551

JO - Pediatric Research

JF - Pediatric Research

IS - 4

ER -

Low bone turnover phenotype in Rett syndrome: Results of biochemical bone marker analysis

Abstract

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