Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Low birth weight and male reproductive function

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Aortic dimensions in girls and young women with Turner syndrome - a magnetic resonance imaging study

    Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

  2. Bridging provocative tests and clinical manifestations of growth hormone deficiency in adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Metabolic aspects of insulin resistance in individuals born small for gestational age

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pegvisomant treatment in a 4-year-old girl with neurofibromatosis type 1

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. GAD65 autoantibodies and glucose tolerance in offspring born to women with and without type 1 diabetes (The EPICOM study)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Brain tumours in children and adolescents may affect the circadian rhythm and quality of life

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Brain tumours result in sleep disorders in children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Scientific interest in morbidity in children born small for gestational age (SGA) has increased considerably over the last few decades. The elevated risk of cardiovascular and metabolic diseases in adulthood in individuals born SGA has been well documented, whereas data on gonadal development are limited. Prospective studies, case-control investigations and registry surveys show that impaired intrauterine growth increases the risks of congenital hypospadias, cryptorchidism and testicular cancer approximately two- to threefold. Although few studies focus on the effect of intrauterine growth on male pubertal development, testicular hormone production or sperm quality, available evidence points towards a subtle impairment of both Sertoli cell and Leydig cell function. Animal studies support the hypothesis that impaired perinatal growth restriction, depending on the timing, can affect postnatal testis size and function into adulthood. Current human data, however, are often based on highly selected hospital populations and lack precise distinctions between low birth weight, SGA, timing of growth restriction and a differentiation of catch-up growth patterns. Despite the methodological inadequacies of individual study results, the combined evidence from all data leaves little doubt that fetal growth restriction is associated with increased risk of male reproductive health problems, including hypospadias, cryptorchidism and testicular cancer.

OriginalsprogEngelsk
TidsskriftHormone Research
Vol/bind65 Suppl 3
Sider (fra-til)116-22
Antal sider7
ISSN0301-0163
DOI
StatusUdgivet - 2006

ID: 45497156