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Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow-up within the QoLiRECT study

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Harvard

Sandberg, S, Asplund, D, Bisgaard, T, Bock, D, González, E, Karlsson, L, Matthiessen, P, Ohlsson, B, Park, J, Rosenberg, J, Skullman, S, Sörensson, M & Angenete, E 2020, 'Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow-up within the QoLiRECT study', Colorectal Disease, bind 22, nr. 10, s. 1367-1378. https://doi.org/10.1111/codi.15095

APA

Sandberg, S., Asplund, D., Bisgaard, T., Bock, D., González, E., Karlsson, L., Matthiessen, P., Ohlsson, B., Park, J., Rosenberg, J., Skullman, S., Sörensson, M., & Angenete, E. (2020). Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow-up within the QoLiRECT study. Colorectal Disease, 22(10), 1367-1378. https://doi.org/10.1111/codi.15095

CBE

MLA

Vancouver

Author

Sandberg, S ; Asplund, D ; Bisgaard, T ; Bock, D ; González, E ; Karlsson, L ; Matthiessen, P ; Ohlsson, B ; Park, J ; Rosenberg, J ; Skullman, S ; Sörensson, M ; Angenete, E. / Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer : a longitudinal follow-up within the QoLiRECT study. I: Colorectal Disease. 2020 ; Bind 22, Nr. 10. s. 1367-1378.

Bibtex

@article{87d667e48e384842b76702a70ead1d92,
title = "Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer: a longitudinal follow-up within the QoLiRECT study",
abstract = "AIM: Low anterior resection syndrome (LARS) is common after low anterior resection. Our aim was to evaluate the prevalence and 'bother' (subjective, symptom-associated distress) of major LARS after 1 and 2 years, identify possible risk factors and relate the bowel function to a reference population.METHOD: The QoLiRECT (Quality of Life in RECTal cancer) study is a Scandinavian prospective multicentre study including 1248 patients with rectal cancer, of whom 552 had an anterior resection. Patient questionnaires were distributed at diagnosis and after 1, 2 and 5 years. Data from the baseline and at 1- and 2-year follow-up were included in this study.RESULTS: The LARS score was calculated for 309 patients at 1 year and 334 patients at 2 years. Prevalence was assessed by a generalized linear mixed effects model. Major LARS was found in 63% at 1 year and 56% at 2 years. Bother was evident in 55% at 1 year, decreasing to 46% at 2 years. Major LARS was most common among younger women (69%). Among younger patients, only marginal improvement was seen over time (63-59%), for older patients there was more improvement (62-52%). In the reference population, the highest prevalence of major LARS-like symptoms was noted in older women (12%). Preoperative radiotherapy, defunctioning stoma and tumour height were found to be associated with major LARS.CONCLUSION: Major LARS is common and possibly persistent over time. Younger patients, especially women, are more affected, and perhaps these patients should be prioritized for early stoma closure to improve the chance of a more normal bowel function.",
author = "S Sandberg and D Asplund and T Bisgaard and D Bock and E Gonz{\'a}lez and L Karlsson and P Matthiessen and B Ohlsson and J Park and J Rosenberg and S Skullman and M S{\"o}rensson and E Angenete",
note = "{\textcopyright} 2020 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.",
year = "2020",
month = oct,
doi = "10.1111/codi.15095",
language = "English",
volume = "22",
pages = "1367--1378",
journal = "Colorectal Disease",
issn = "1462-8910",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "10",

}

RIS

TY - JOUR

T1 - Low anterior resection syndrome in a Scandinavian population of patients with rectal cancer

T2 - a longitudinal follow-up within the QoLiRECT study

AU - Sandberg, S

AU - Asplund, D

AU - Bisgaard, T

AU - Bock, D

AU - González, E

AU - Karlsson, L

AU - Matthiessen, P

AU - Ohlsson, B

AU - Park, J

AU - Rosenberg, J

AU - Skullman, S

AU - Sörensson, M

AU - Angenete, E

N1 - © 2020 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland.

PY - 2020/10

Y1 - 2020/10

N2 - AIM: Low anterior resection syndrome (LARS) is common after low anterior resection. Our aim was to evaluate the prevalence and 'bother' (subjective, symptom-associated distress) of major LARS after 1 and 2 years, identify possible risk factors and relate the bowel function to a reference population.METHOD: The QoLiRECT (Quality of Life in RECTal cancer) study is a Scandinavian prospective multicentre study including 1248 patients with rectal cancer, of whom 552 had an anterior resection. Patient questionnaires were distributed at diagnosis and after 1, 2 and 5 years. Data from the baseline and at 1- and 2-year follow-up were included in this study.RESULTS: The LARS score was calculated for 309 patients at 1 year and 334 patients at 2 years. Prevalence was assessed by a generalized linear mixed effects model. Major LARS was found in 63% at 1 year and 56% at 2 years. Bother was evident in 55% at 1 year, decreasing to 46% at 2 years. Major LARS was most common among younger women (69%). Among younger patients, only marginal improvement was seen over time (63-59%), for older patients there was more improvement (62-52%). In the reference population, the highest prevalence of major LARS-like symptoms was noted in older women (12%). Preoperative radiotherapy, defunctioning stoma and tumour height were found to be associated with major LARS.CONCLUSION: Major LARS is common and possibly persistent over time. Younger patients, especially women, are more affected, and perhaps these patients should be prioritized for early stoma closure to improve the chance of a more normal bowel function.

AB - AIM: Low anterior resection syndrome (LARS) is common after low anterior resection. Our aim was to evaluate the prevalence and 'bother' (subjective, symptom-associated distress) of major LARS after 1 and 2 years, identify possible risk factors and relate the bowel function to a reference population.METHOD: The QoLiRECT (Quality of Life in RECTal cancer) study is a Scandinavian prospective multicentre study including 1248 patients with rectal cancer, of whom 552 had an anterior resection. Patient questionnaires were distributed at diagnosis and after 1, 2 and 5 years. Data from the baseline and at 1- and 2-year follow-up were included in this study.RESULTS: The LARS score was calculated for 309 patients at 1 year and 334 patients at 2 years. Prevalence was assessed by a generalized linear mixed effects model. Major LARS was found in 63% at 1 year and 56% at 2 years. Bother was evident in 55% at 1 year, decreasing to 46% at 2 years. Major LARS was most common among younger women (69%). Among younger patients, only marginal improvement was seen over time (63-59%), for older patients there was more improvement (62-52%). In the reference population, the highest prevalence of major LARS-like symptoms was noted in older women (12%). Preoperative radiotherapy, defunctioning stoma and tumour height were found to be associated with major LARS.CONCLUSION: Major LARS is common and possibly persistent over time. Younger patients, especially women, are more affected, and perhaps these patients should be prioritized for early stoma closure to improve the chance of a more normal bowel function.

U2 - 10.1111/codi.15095

DO - 10.1111/codi.15095

M3 - Journal article

C2 - 32346917

VL - 22

SP - 1367

EP - 1378

JO - Colorectal Disease

JF - Colorectal Disease

SN - 1462-8910

IS - 10

ER -

ID: 62071640