Abstrakt
We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant disrupts a splice acceptor site, and carriers have decreased ADCY3 RNA expression. Additionally, we observe an enrichment of rare ADCY3 loss-of-function variants among individuals with type 2 diabetes in trans-ancestry cohorts. These findings provide new information on disease etiology relevant for future treatment strategies.
Originalsprog | Engelsk |
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Tidsskrift | Nature Genetics |
Vol/bind | 50 |
Sider (fra-til) | 172-174 |
Antal sider | 2 |
ISSN | 1061-4036 |
DOI | |
Status | Udgivet - jan. 2018 |