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Long-term survival, health, social functioning, and education in patients with an enterovirus central nervous system infection, Denmark, 1997-2016

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@article{04a728ce73664c66a709f79efd56f1e2,
title = "Long-term survival, health, social functioning, and education in patients with an enterovirus central nervous system infection, Denmark, 1997-2016",
abstract = "BACKGROUND: The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.METHODS: We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997-2016 (n = 1745) and a comparison cohort from the general population individually matched on date of birth and sex (n = 17 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.RESULTS: Mortality in the first year was higher among patients with ECI (mortality rate ratio [MRR] = 10.0; 95{\%} confidence interval [CI], 4.17-24.1), but thereafter mortality was not higher (MMR = 0.94; 95{\%} CI, 0.47-1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.CONCLUSIONS: Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.",
keywords = "Enterovirus meningitis, Meningitis, Viral meningitis",
author = "Omland, {Lars H} and Charlotte Holm-Hansen and Anne-Mette Lebech and Dessau, {Ram B} and Jacob Bodilsen and Andersen, {Nanna S} and Casper Roed and Christiansen, {Claus B} and Svend Ellermann-Eriksen and Sofie Midgley and Lene Nielsen and Thomas Benfield and Hansen, {Ann-Brit E} and Andersen, {Christian {\O}} and Rothman, {Kenneth J} and S{\o}rensen, {Henrik T} and Fischer, {Thea K} and Niels Obel",
note = "{\circledC} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = "7",
day = "23",
doi = "10.1093/infdis/jiaa151",
language = "English",
volume = "222",
pages = "619--627",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "University of Chicago Press",
number = "4",

}

RIS

TY - JOUR

T1 - Long-term survival, health, social functioning, and education in patients with an enterovirus central nervous system infection, Denmark, 1997-2016

AU - Omland, Lars H

AU - Holm-Hansen, Charlotte

AU - Lebech, Anne-Mette

AU - Dessau, Ram B

AU - Bodilsen, Jacob

AU - Andersen, Nanna S

AU - Roed, Casper

AU - Christiansen, Claus B

AU - Ellermann-Eriksen, Svend

AU - Midgley, Sofie

AU - Nielsen, Lene

AU - Benfield, Thomas

AU - Hansen, Ann-Brit E

AU - Andersen, Christian Ø

AU - Rothman, Kenneth J

AU - Sørensen, Henrik T

AU - Fischer, Thea K

AU - Obel, Niels

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/7/23

Y1 - 2020/7/23

N2 - BACKGROUND: The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.METHODS: We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997-2016 (n = 1745) and a comparison cohort from the general population individually matched on date of birth and sex (n = 17 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.RESULTS: Mortality in the first year was higher among patients with ECI (mortality rate ratio [MRR] = 10.0; 95% confidence interval [CI], 4.17-24.1), but thereafter mortality was not higher (MMR = 0.94; 95% CI, 0.47-1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.CONCLUSIONS: Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.

AB - BACKGROUND: The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.METHODS: We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997-2016 (n = 1745) and a comparison cohort from the general population individually matched on date of birth and sex (n = 17 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae: neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.RESULTS: Mortality in the first year was higher among patients with ECI (mortality rate ratio [MRR] = 10.0; 95% confidence interval [CI], 4.17-24.1), but thereafter mortality was not higher (MMR = 0.94; 95% CI, 0.47-1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.CONCLUSIONS: Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.

KW - Enterovirus meningitis

KW - Meningitis

KW - Viral meningitis

UR - http://www.scopus.com/inward/record.url?scp=85088531687&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiaa151

DO - 10.1093/infdis/jiaa151

M3 - Journal article

VL - 222

SP - 619

EP - 627

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -

ID: 59633259