Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Long-term quality of life & functional outcomes after treatment of oropharyngeal cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. The optimal cut-off value in fit-based colorectal cancer screening: An observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Breast cancer survivors' risk of interval cancers and false positive results in organized mammography screening

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Depression and anxiety in Hodgkin lymphoma patients: A Danish nationwide cohort study of 945 patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Impact of chronic diseases on effect of breast cancer screening

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Functional and QoL outcomes were compared longitudinally in a cohort of patients treated for oropharyngeal squamous cell carcinoma (OPSCC) with primary transoral robotic surgery (TORS) or radiotherapy (RT). Forty-four patients undergoing primary TORS (n = 31) or RT (n = 13) for any stage OPSCC were included. Only low-stage disease was treated with TORS. Functional outcomes were: salivary flow rate, image-based swallowing function, and a self-reported 10-point scale comparing current swallowing function to baseline (CvB scale). QoL was assessed with European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30), Head & Neck Module (EORTC QLQ-HN35), and MD Anderson Dysphagia Inventory (MDADI). Shoulder impairment was assessed with Neck Dissection Impairment Index (NDII) and Oxford Shoulder Score (OSS). In the RT group, salivary flow rates had significantly declined at 12-month follow-up, with the biggest declines in QoL subscale scores recorded in the RT group for dry mouth and sticky saliva. Swallowing function on imaging studies was overall good, with no severe dysphagia within 1 year although, both treatment groups showed significant deterioration relative to baseline at the 12-month follow-up with increased DIGEST scores and pharyngeal retention. Shoulder impairment was rare at 1 year in both groups. A comprehensive examination of this cohort treated for OPSCC showed overall good functional and QoL outcomes 1 year after treatment. However, persistent impairment was seen in both groups with regards to swallowing function. In the TORS group, at 12-months follow-up, the QoL questionnaires showed worse scores in only one subscale (sticky saliva).

TidsskriftCancer Medicine
Udgave nummer2
Sider (fra-til)483-495
Antal sider13
StatusUdgivet - 2021

Bibliografisk note

© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

ID: 61403993