Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Long-term Outcomes of Temporomandibular Joints in Juvenile Idiopathic Arthritis: 17 Years of Followup of a Nordic Juvenile Idiopathic Arthritis Cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Adaptive Trial Designs in Rheumatology: Report from the OMERACT Special Interest Group

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Phenotypic variability in Muenke syndrome-observations from five Danish families

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Primary failure of eruption of teeth in two siblings with a novel mutation in the PTH1R gene

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Novel de novo mutation in ZBTB20 in primrose syndrome in boy with short stature

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Mia Glerup
  • Peter Stoustrup
  • Louise Matzen
  • Veronika Rypdal
  • Ellen Nordal
  • Paula Frid
  • Ellen Dalen Arnstad
  • Marite Rygg
  • Olafur Thorarensen
  • Maria Ekelund
  • Lillemor Berntson
  • Anders Fasth
  • Håkan Nilsson
  • Suvi Peltoniemi
  • Kristiina Aalto
  • Sirpa Arte
  • Peter Toftedal
  • Susan Nielsen
  • Sven Kreiborg
  • Troels Herlin
  • Thomas Klit Pedersen
Vis graf over relationer

OBJECTIVE: To determine the prevalence of orofacial symptoms, dysfunctions, and deformities of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) 17 years after disease onset.

METHODS: Drawn from a prospective, population-based Nordic JIA cohort with disease onset from 1997 to 2000, 420 consecutive cases were eligible for orofacial evaluation of TMJ involvement. The followup visit included demographic data, a standardized clinical orofacial examination, and full-face cone-beam computed tomography (CBCT). For comparison, 200 age-matched healthy controls were used.

RESULTS: Of 420 eligible participants with JIA, 265 (63%) were included (mean age 23.5 ± 4.2 yrs) and completed a standardized clinical orofacial examination. Of these, 245 had a full-face CBCT performed. At least 1 orofacial symptom was reported by 33%. Compared to controls, the JIA group significantly more often reported TMJ pain, TMJ morning stiffness, and limitation on chewing. Further, among participants reporting complaints, the number of symptoms was also higher in JIA. The mean maximal incisal opening was lower in the JIA group (p < 0.001), and TMJ pain on palpation was more frequent. Condylar deformities and/or erosions were observed in 61% as assessed by CBCT, showing bilateral changes in about 70%. Risk factors of condylar deformities were orofacial dysfunction or biologic treatment; enthesitis-related arthritis was protective.

CONCLUSION: This study of the longterm consequences of TMJ involvement in a population-based JIA cohort reports persistence of comprehensive symptoms, dysfunctions, and damage of the TMJ into adulthood. We suggest interdisciplinary followup of JIA patients also in adulthood.

TidsskriftJournal of Rheumatology
Udgave nummer5
Sider (fra-til)730-738
Antal sider9
StatusUdgivet - 1 maj 2020

ID: 58928617