Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Long-Term Metastatic Risk after Biopsy of Posterior Uveal Melanoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Peripapillary Ovoid Hyperreflectivity in Optic Disc Edema and Pseudopapilledema

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Adrenal Suppression in Infants Treated with Topical Ocular Glucocorticoids

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Myopic Choroidal Neovascularization: Review, Guidance, and Consensus Statement on Management

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Operating Room Performance Improves after Proficiency-Based Virtual Reality Cataract Surgery Training

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association of Choroidal Effusion and Infusion of Daratumumab

    Publikation: Bidrag til tidsskriftLetterForskning

  3. Inverted papilloma of the conjunctiva

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. KRAS mutations in the parental tumour accelerate in vitro growth of tumoroids established from colorectal adenocarcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Periocular necrotizing soft tissue infection in Greater Copenhagen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE: Biopsy of posterior uveal melanoma continues to be intensely debated in terms of the clinical benefits and safety profile. Although several studies have reported a low frequency of ocular complications after tumor biopsy, the potential long-term risk of iatrogenic dissemination remains unresolved. The purpose of this study was to assess the risk of metastatic disease after biopsy of posterior uveal melanoma.

DESIGN: Retrospective nationwide cohort study linking clinical and histopathologic records to pathology, cancer, and mortality registries.

PARTICIPANTS: All patients with posterior uveal melanoma treated in Denmark between January 1985 and December 2016.

METHODS: For each patient, we recorded detailed information on age, gender, tumor characteristics, and diagnostic and therapeutic measures, including tumor biopsy, if any, and the primary treating hospital. Absolute risk of melanoma-specific death was presented by cumulative incidence curves that accounted for competing risks. Cox regression models were used to estimate crude and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and melanoma-specific mortality of patients who underwent biopsy during primary treatment compared with nonbiopsied patients through November 1, 2017. Fine and Gray risk regression was used as a sensitivity analysis to evaluate the impact of competing risks.

MAIN OUTCOME MEASURES: All-cause and melanoma-specific mortality.

RESULTS: Among 1637 patients, 567 (35%) underwent biopsy during primary treatment. At diagnosis, biopsied patients exhibited better prognostic characteristics, including smaller tumor size (P < 0.001) and younger age (P < 0.001), than nonbiopsied patients. In the adjusted analyses, we observed no apparent differences in all-cause mortality (HR, 1.07; 95% CI, 0.89-1.26; P = 0.47) or melanoma-specific mortality (HR, 1.11; 95% CI, 0.89-1.39; P = 0.35) among biopsied patients compared with nonbiopsied patients.

CONCLUSIONS: All-cause and melanoma-specific mortality after primary treatment were similar among biopsied and nonbiopsied patients with posterior uveal melanoma. Our findings do not support an increased metastatic risk after intraocular tumor biopsy.

OriginalsprogEngelsk
TidsskriftOphthalmology
Vol/bind125
Udgave nummer12
Sider (fra-til)1969-1976
Antal sider7
ISSN0161-6420
DOI
StatusUdgivet - 2018

ID: 53721294