Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Long-term Iodine nutrition is associated with longevity in older adults: a 20 years' follow-up of the Randers-Skagen study

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  • Johannes Riis
  • Klaus M Pedersen
  • Mathias B Danielsen
  • Gustav V B Sørensen
  • Martin G Jørgensen
  • Stine L Andersen
  • Allan Carlé
  • Inge B Pedersen
  • Christian Torp-Pedersen
  • Stig Andersen
Vis graf over relationer

Iodine intake affects the occurrence of thyroid disorders. However, the association of iodine intake with longevity remains to be described. This led us to perform a 20 years' follow-up on participants from the Randers-Skagen (RaSk) study. Residents in Randers born in 1920 (n 210) and Skagen born in 1918-1923 (n 218) were included in a clinical study in 1997-1998. Mean iodine content in drinking water was 2 µg/l in Randers and 139 µg/l in Skagen. We collected baseline data through questionnaires, performed physical examinations and measured iodine concentrations in spot urine samples. Income data were retrieved from Danish registries. We performed follow-up on mortality until 31 December 2017 using Danish registries. Complete follow-up data were available on 428 out of 430 of participants (99·5 %). At baseline, the median urinary iodine concentration was 55 µg/l in Randers and 160 µg/l in Skagen residents. Participants were long-term residents with 72·8 and 92·7 % residing for more than 25 years in Randers and Skagen, respectively. Cox regression showed that living in Skagen compared with Randers was associated with a lower hazard ratio (HR) of death in both age- and sex-adjusted analyses (HR 0·60, 95 % CI 0·41, 0·87, P = 0·006), but also after adjustment for age, sex, number of drugs, Charlson co-morbidity index, smoking, alcohol and income (HR 0·60, 95 % CI 0·41, 0·87, P = 0·008). Residing in iodine-replete Skagen was associated with increased longevity. This indicates that long-term residency in an iodine-replete environment may be associated with increased longevity compared with residency in an iodine-deficient environment.

OriginalsprogEngelsk
TidsskriftThe British journal of nutrition
Vol/bind125
Udgave nummer3
Sider (fra-til)260-265
Antal sider6
ISSN0007-1145
DOI
StatusUdgivet - 2021

ID: 59910110