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Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Harvard

Johannsen, TH, Ripa, CPL, Carlsen, E, Linde, JS, Nielsen, OH, Hansen-Schwartz, JAS, Drzewiecki, KT, Mortensen, EL & Main, KM 2010, 'Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency' International journal of pediatric endocrinology, bind 2010, s. 784297. https://doi.org/10.1155/2010/784297

APA

Johannsen, T. H., Ripa, C. P. L., Carlsen, E., Linde, J. S., Nielsen, O. H., Hansen-Schwartz, J. A. S., ... Main, K. M. (2010). Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. International journal of pediatric endocrinology, 2010, 784297. https://doi.org/10.1155/2010/784297

CBE

Johannsen TH, Ripa CPL, Carlsen E, Linde JS, Nielsen OH, Hansen-Schwartz JAS, Drzewiecki KT, Mortensen EL, Main KM. 2010. Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. International journal of pediatric endocrinology. 2010:784297. https://doi.org/10.1155/2010/784297

MLA

Johannsen, T H o.a.. "Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency". International journal of pediatric endocrinology. 2010, 2010. 784297. https://doi.org/10.1155/2010/784297

Vancouver

Johannsen TH, Ripa CPL, Carlsen E, Linde JS, Nielsen OH, Hansen-Schwartz JAS o.a. Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. International journal of pediatric endocrinology. 2010 jan 1;2010:784297. https://doi.org/10.1155/2010/784297

Author

Johannsen, T H ; Ripa, Caroline P.L. ; Carlsen, E ; Linde, Jakob Starup ; Nielsen, O H ; Hansen-Schwartz, Jacob Andreas Saturnino ; Drzewiecki, K T ; Mortensen, E L ; Main, K M. / Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. I: International journal of pediatric endocrinology. 2010 ; Bind 2010. s. 784297.

Bibtex

@article{11b20fd80f074458b4ac2f7e101fccee,
title = "Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency",
abstract = "Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2-8], P <.001), shorter vaginal length (121 mm [100-155] versus 128 [112-153], P = .12), lower uterine volumes (29.1 ml [7.5-56.7] versus 47.4 [15.9-177.5], P = .009), and higher ovarian volumes (4.4 ml [1.3-10.8] versus 2.8 [0.6-10.8], P = .09) than controls. Satisfaction with genital appearance was lower and negatively correlated to degree of initial virilisation (r(s) = ≤-0.39, P ≤ .05). More patients had never had intercourse (P = .001), and age at 1st intercourse was higher (18 yrs versus 16 yrs, P = .02). Conclusion. Despite overall acceptable cosmetic results, reproductive outcomes were suboptimal, supporting that multidisciplinary teams should be involved in adult follow up of CAH patients.",
author = "Johannsen, {T H} and Ripa, {Caroline P.L.} and E Carlsen and Linde, {Jakob Starup} and Nielsen, {O H} and Hansen-Schwartz, {Jacob Andreas Saturnino} and Drzewiecki, {K T} and Mortensen, {E L} and Main, {K M}",
year = "2010",
month = "1",
day = "1",
doi = "10.1155/2010/784297",
language = "English",
volume = "2010",
pages = "784297",
journal = "International Journal of Pediatric Endocrinology",
issn = "1687-9848",
publisher = "BioMed Central Ltd",

}

RIS

TY - JOUR

T1 - Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

AU - Johannsen, T H

AU - Ripa, Caroline P.L.

AU - Carlsen, E

AU - Linde, Jakob Starup

AU - Nielsen, O H

AU - Hansen-Schwartz, Jacob Andreas Saturnino

AU - Drzewiecki, K T

AU - Mortensen, E L

AU - Main, K M

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2-8], P <.001), shorter vaginal length (121 mm [100-155] versus 128 [112-153], P = .12), lower uterine volumes (29.1 ml [7.5-56.7] versus 47.4 [15.9-177.5], P = .009), and higher ovarian volumes (4.4 ml [1.3-10.8] versus 2.8 [0.6-10.8], P = .09) than controls. Satisfaction with genital appearance was lower and negatively correlated to degree of initial virilisation (r(s) = ≤-0.39, P ≤ .05). More patients had never had intercourse (P = .001), and age at 1st intercourse was higher (18 yrs versus 16 yrs, P = .02). Conclusion. Despite overall acceptable cosmetic results, reproductive outcomes were suboptimal, supporting that multidisciplinary teams should be involved in adult follow up of CAH patients.

AB - Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2-8], P <.001), shorter vaginal length (121 mm [100-155] versus 128 [112-153], P = .12), lower uterine volumes (29.1 ml [7.5-56.7] versus 47.4 [15.9-177.5], P = .009), and higher ovarian volumes (4.4 ml [1.3-10.8] versus 2.8 [0.6-10.8], P = .09) than controls. Satisfaction with genital appearance was lower and negatively correlated to degree of initial virilisation (r(s) = ≤-0.39, P ≤ .05). More patients had never had intercourse (P = .001), and age at 1st intercourse was higher (18 yrs versus 16 yrs, P = .02). Conclusion. Despite overall acceptable cosmetic results, reproductive outcomes were suboptimal, supporting that multidisciplinary teams should be involved in adult follow up of CAH patients.

U2 - 10.1155/2010/784297

DO - 10.1155/2010/784297

M3 - Journal article

VL - 2010

SP - 784297

JO - International Journal of Pediatric Endocrinology

JF - International Journal of Pediatric Endocrinology

SN - 1687-9848

ER -

ID: 32184099