Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. No long-term effect of oral stimulation on the intra-oral vacuum in healthy premature infants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Randomised oral stimulation and exclusive breastfeeding duration in healthy premature infants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Menstrual Pattern, Reproductive Hormones and Transabdominal 3D Ultrasound in 317 Adolescent Girls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2-30] versus 3.5 [2-8], P <.001), shorter vaginal length (121 mm [100-155] versus 128 [112-153], P = .12), lower uterine volumes (29.1 ml [7.5-56.7] versus 47.4 [15.9-177.5], P = .009), and higher ovarian volumes (4.4 ml [1.3-10.8] versus 2.8 [0.6-10.8], P = .09) than controls. Satisfaction with genital appearance was lower and negatively correlated to degree of initial virilisation (r(s) = ≤-0.39, P ≤ .05). More patients had never had intercourse (P = .001), and age at 1st intercourse was higher (18 yrs versus 16 yrs, P = .02). Conclusion. Despite overall acceptable cosmetic results, reproductive outcomes were suboptimal, supporting that multidisciplinary teams should be involved in adult follow up of CAH patients.
OriginalsprogEngelsk
TidsskriftInternational journal of pediatric endocrinology
Vol/bind2010
Sider (fra-til)784297
DOI
StatusUdgivet - 1 jan. 2010

ID: 32184099