Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Longitudinal study of electrical, functional and structural remodelling in an equine model of atrial fibrillation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Next-generation sequencing using microfluidic PCR enrichment for molecular autopsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Sudden Cardiac Death in the Young

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Potassium Disturbances and Risk of Ventricular Fibrillation Among Patients With ST-Segment-Elevation Myocardial Infarction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Large animal models are important in atrial fibrillation (AF) research, as they can be used to study the pathophysiology of AF and new therapeutic approaches. Unlike other animal models, horses spontaneously develop AF and could therefore serve as a bona fide model in AF research. We therefore aimed to study the electrical, functional and structural remodelling caused by chronic AF in a horse model.

METHOD: Nine female horses were included in the study, with six horses tachypaced into self-sustained AF and three that served as a time-matched sham-operated control group. Acceleration in atrial fibrillatory rate (AFR), changes in electrocardiographic and echocardiographic variables and response to medical treatment (flecainide 2 mg/kg) were recorded over a period of 2 months. At the end of the study, changes in ion channel expression and fibrosis were measured and compared between the two groups.

RESULTS: AFR increased from 299 ± 33 fibrillations per minute (fpm) to 376 ± 12 fpm (p < 0.05) and atrial function (active left atrial fractional area change) decreased significantly during the study (p < 0.05). No changes were observed in heart rate or ventricular function. The AF group had more atrial fibrosis compared to the control group (p < 0.05). No differences in ion channel expression were observed.

CONCLUSION: Horses with induced AF show signs of atrial remodelling that are similar to humans and other animal models.

OriginalsprogEngelsk
TidsskriftBMC Cardiovascular Disorders
Vol/bind19
Udgave nummer1
Sider (fra-til)228
ISSN1471-2261
DOI
StatusUdgivet - 21 okt. 2019

ID: 59172075