Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Longitudinal change in cardiac structure and function following acute coronary syndrome according to culprit coronary artery lesion

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Left atrial contractile strain predicts recurrence of atrial tachyarrhythmia after catheter ablation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Global and regional wall motion abnormalities and incident heart failure in the general population

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The metabolic signature of cardiovascular disease and arterial calcification in patients with chronic kidney disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Acute coronary syndrome (ACS) may lead to adverse remodelling and impaired cardiac function. Limited data exists on the effect of culprit coronary artery lesion site and impact on longitudinal cardiac remodelling. The present study included a total of 299 patients suffering from ACS treated with percutaneous coronary intervention (PCI). All patients had two echocardiographic examinations. The first echocardiography was median 2(IQR: 1;3) days following PCI, while the follow-up echocardiography (FUE) was median 257(IQR: 96;942) days following the first. Patients were grouped based on coronary artery PCI location; left anterior descending artery (LAD), right coronary artery (RCA) or circumflex artery (Cx). Patients with multiple lesions were excluded. Mean age was 63 ± 11 years and 77% were male. At FUE, mean left ventricular ejection fraction was 42 ± 9% and global longitudinal strain (GLS) was − 13 ± 4%. PCI treatment was allocated as 168 LAD lesions, 95 RCA lesions, and 36 Cx lesions. Linear regression analysis showed that patients with a LAD lesion displayed worsening in E/A (mean ∆ = 0.05, β = − 0.196, p = 0.001) and a larger increase in LVEDV (mean ∆ = 33.18 mL, β = 0.135, p = 0.012). Meanwhile patients with Cx lesion were significantly associated with a larger decrease in E/e′ (mean ∆ = 2.6, β = − 0.120, p = 0.028). Patients with Cx lesion were observed to have elevated E/e′ at baseline, which normalized at FUE. The present study suggests that culprit coronary artery lesion has a differential impact on myocardial remodelling. This information may potentially aid in understanding the pathophysiological differences in cardiac structure and function amongst patients with ACS.

TidsskriftInternational Journal of Cardiovascular Imaging
Udgave nummer5
Sider (fra-til)1029-1036
Antal sider8
StatusE-pub ahead of print - 2022

Bibliografisk note

Funding Information:
KR was funded by a research grant from the Novo Nordic Foundation. The sponsors had no role in the study concept, design, conduction, or interpretation of the data.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature B.V.

ID: 75347184