Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements

Tea Skaaby, Lise Lotte Nystrup Husemoen, Betina Heinsbæk Thuesen, Charlotta Pisinger, Anke Hannemann, Torben Jørgensen, Allan Linneberg

38 Citationer (Scopus)

Abstrakt

Several lifestyle factors have been found to be associated with vitamin D status in cross-sectional studies, but it is not clear whether a change in these factors can actually affect the vitamin D level. We investigated the association between repeated measurements of physical activity, body mass index (BMI), diet, alcohol consumption, and smoking habits, and corresponding levels of vitamin D during 5 years of follow-up of a large general population sample. We included 4185 persons who participated and had vitamin D (serum-25-hydroxyvitamin D, 25-OH-D) measurements in the Inter99 study at baseline (1999-2001) and 5-year follow-up. In a subsample, 25-OH-D was also measured at 1- and 3-year follow-ups. We used mixed models to examine the association between repeated measurements of lifestyle factors and 25-OH-D levels. In multivariable analyses of repeated measurements, the difference in 25-OH-D was -0.32 ng/ml (95 % CI -0.37, -0.28) per 1 kg/m(2) increase in BMI; 4.50 ng/ml (95 % CI 3.84, 5.15) for persons moderately/vigorously physically active versus sedentary; 1.82 ng/ml (95 % CI 1.09, 2.56) for persons with healthy versus unhealthy dietary habits; 0.05 ng/ml (95 % CI 0.03, 0.07) per 1 standard drink/weak increase in alcohol consumption; and 0.86 ng/ml (95 % CI 0.36, 1.35) for never smokers versus daily smokers. Our study shows that lower BMI, a higher level of physical activity, a healthier diet and possibly a higher alcohol intake, and not smoking, are associated with higher 25-OH-D levels.

OriginalsprogEngelsk
TidsskriftEndocrine
Vol/bind51
Udgave nummer2
Sider (fra-til)342-50
Antal sider9
ISSN1355-008X
DOI
StatusUdgivet - 30 maj 2016

Fingeraftryk

Dyk ned i forskningsemnerne om 'Longitudinal associations between lifestyle and vitamin D: A general population study with repeated vitamin D measurements'. Sammen danner de et unikt fingeraftryk.

Citationsformater