TY - JOUR
T1 - Long-term trends in the incidence of type 1 diabetes in Denmark: the seasonal variation changes over time
AU - Svensson, Jannet
AU - Lyngaae-Jørgensen, Annette
AU - Carstensen, Bendix
AU - Simonsen, Lars Bjarke
AU - Mortensen, Henrik B
AU - Danish Childhood Diabetes Registry
N1 - Keywords: Adolescent; Child; Child, Preschool; Denmark; Diabetes Mellitus, Type 1; Female; Forecasting; Humans; Incidence; Infant; Infant, Newborn; Male; Registries; Seasons; Time Factors
PY - 2009
Y1 - 2009
N2 - There is a worldwide increase of type 1 diabetes mellitus (T1DM). In 1996, the Danish population-based registry was initiated including all newly diagnosed children aged 0-15 yr. This is the report of incidence and seasonal variation for the first 10 yr of the registry. The data was analyzed using Poisson's regression analysis. A total of 2166 children with diabetes were diagnosed before the age of 15 yr between 1996 and 2005. In this period, the annual increase in childhood T1DM was 3.43% (95% confidence interval: 1.91-4.97), which was unaffected by age and gender. Seasonal variation in incidence rates varied by year but not by age and gender. In conclusion, there is a steep increase in incidence of childhood T1DM in Denmark; the increase is comparable with the increase seen in other European countries. There is a significant seasonal variation that changes on a year-to-year basis. The observed variations in cadence rates may be associated with viral epidemics, sunshine exposure, or vitamin D levels and suggest further exploration of these relations.
AB - There is a worldwide increase of type 1 diabetes mellitus (T1DM). In 1996, the Danish population-based registry was initiated including all newly diagnosed children aged 0-15 yr. This is the report of incidence and seasonal variation for the first 10 yr of the registry. The data was analyzed using Poisson's regression analysis. A total of 2166 children with diabetes were diagnosed before the age of 15 yr between 1996 and 2005. In this period, the annual increase in childhood T1DM was 3.43% (95% confidence interval: 1.91-4.97), which was unaffected by age and gender. Seasonal variation in incidence rates varied by year but not by age and gender. In conclusion, there is a steep increase in incidence of childhood T1DM in Denmark; the increase is comparable with the increase seen in other European countries. There is a significant seasonal variation that changes on a year-to-year basis. The observed variations in cadence rates may be associated with viral epidemics, sunshine exposure, or vitamin D levels and suggest further exploration of these relations.
U2 - 10.1111/j.1399-5448.2008.00483.x
DO - 10.1111/j.1399-5448.2008.00483.x
M3 - Journal article
C2 - 19067889
SN - 1399-543X
VL - 10
SP - 248
EP - 254
JO - Pediatric Diabetes
JF - Pediatric Diabetes
IS - 4
ER -