Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function

Finn Gustafsson, Christian Torp-Pedersen, Bente Brendorp, Marie Seibaek, Hans Burchardt, Lars Køber, DIAMOND Study Group

Abstract

AIMS: The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis.

METHODS AND RESULTS: Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993-1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5-8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56-0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%).

CONCLUSION: In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function.

OriginalsprogEngelsk
TidsskriftEuropean Heart Journal
Vol/bind24
Udgave nummer9
Sider (fra-til)863-70
Antal sider8
ISSN0195-668X
DOI
StatusUdgivet - maj 2003
Udgivet eksterntJa

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