Long-Term Exposure to Transportation Noise and Ischemic Heart Disease: A Pooled Analysis of Nine Scandinavian Cohorts

Andrei Pyko, Nina Roswall, Mikael Ögren, Anna Oudin, Annika Rosengren, Charlotta Eriksson, David Segersson, Debora Rizzuto, Eva M Andersson, Gunn Marit Aasvang, Gunnar Engström, Hrafnhildur Gudjonsdottir, Jeanette T Jørgensen, Jenny Selander, Jesper H Christensen, Jørgen Brandt, Karin Leander, Kim Overvad, Kristina Eneroth, Kristoffer MattissonLars Barregard, Leo Stockfelt, Maria Albin, Mette K Simonsen, Pekka Tiittanen, Peter Molnar, Petter Ljungman, Steen Solvang Jensen, Susanna Gustafsson, Timo Lanki, Youn-Hee Lim, Zorana J Andersen, Mette Sørensen, Göran Pershagen


BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear.

OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes.

METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors.

RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB Lden for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB Lden for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB Lden was suggested in the exposure-response relation for road traffic noise and IHD.

DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/EHP10745.

TidsskriftEnvironmental Health Perspectives
Udgave nummer1
Antal sider11
StatusUdgivet - jan. 2023


Dyk ned i forskningsemnerne om 'Long-Term Exposure to Transportation Noise and Ischemic Heart Disease: A Pooled Analysis of Nine Scandinavian Cohorts'. Sammen danner de et unikt fingeraftryk.