Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

John C Mathers; Mohammad Movahedi; Finlay Macrae; Jukka-Pekka Mecklin; Gabriela Moeslein; Sylviane Olschwang; Diana Eccles; Gareth Evans; Eamonn R Maher; Lucio Bertario; Søs Marie Luise Bisgaard; Malcolm Dunlop; Judy W C Ho; Shirley Hodgson; Annika Lindblom; Jan Lubinski; Patrick J Morrison; Victoria Murday; Raj Ramesar; Lucy Side; Rodney J Scott; Huw J W Thomas; Hans Vasen; Anne-Marie Gerdes; Gail Barker; Gillian Crawford; Faye Elliott; Kirsi Pylvanainen; Juul Wijnen; Riccardo Fodde; Henry Lynch; D Timothy Bishop; John Burn; CAPP2 Investigators

doi:10.1016/S1470-2045(12)70475-8

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

John C Mathers, Mohammad Movahedi, Finlay Macrae, Jukka-Pekka Mecklin, Gabriela Moeslein, Sylviane Olschwang, Diana Eccles, Gareth Evans, Eamonn R Maher, Lucio Bertario, Søs Marie Luise Bisgaard, Malcolm Dunlop, Judy W C Ho, Shirley Hodgson, Annika Lindblom, Jan Lubinski, Patrick J Morrison, Victoria Murday, Raj Ramesar, Lucy SideRodney J Scott, Huw J W Thomas, Hans Vasen, Anne-Marie Gerdes, Gail Barker, Gillian Crawford, Faye Elliott, Kirsi Pylvanainen, Juul Wijnen, Riccardo Fodde, Henry Lynch, D Timothy Bishop, John Burn, CAPP2 Investigators

Afdeling for Genetik DIA

89 Citationer (Scopus)

Abstract

Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.

Originalsprog	Engelsk
Tidsskrift	Lancet Oncology
Vol/bind	13
Udgave nummer	12
Sider (fra-til)	1242-9
Antal sider	8
ISSN	1470-2045
DOI	https://doi.org/10.1016/S1470-2045(12)70475-8
Status	Udgivet - 2012

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10.1016/S1470-2045(12)70475-8

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Mathers, J. C., Movahedi, M., Macrae, F., Mecklin, J.-P., Moeslein, G., Olschwang, S., Eccles, D., Evans, G., Maher, E. R., Bertario, L., Bisgaard, S. M. L., Dunlop, M., Ho, J. W. C., Hodgson, S., Lindblom, A., Lubinski, J., Morrison, P. J., Murday, V., Ramesar, R., ... CAPP2 Investigators (2012). Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncology, 13(12), 1242-9. https://doi.org/10.1016/S1470-2045(12)70475-8

Mathers, JC, Movahedi, M, Macrae, F, Mecklin, J-P, Moeslein, G, Olschwang, S, Eccles, D, Evans, G, Maher, ER, Bertario, L, Bisgaard, SML, Dunlop, M, Ho, JWC, Hodgson, S, Lindblom, A, Lubinski, J, Morrison, PJ, Murday, V, Ramesar, R, Side, L, Scott, RJ, Thomas, HJW, Vasen, H, Gerdes, A-M, Barker, G, Crawford, G, Elliott, F, Pylvanainen, K, Wijnen, J, Fodde, R, Lynch, H, Bishop, DT, Burn, J & CAPP2 Investigators 2012, 'Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial', Lancet Oncology, bind 13, nr. 12, s. 1242-9. https://doi.org/10.1016/S1470-2045(12)70475-8

@article{097509b8b50549f682ee563847be72e8,

title = "Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial",

abstract = "Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.",

keywords = "Adult, Aged, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Dietary Carbohydrates, Dietary Fiber, Double-Blind Method, Female, Germ-Line Mutation, Heterozygote, Humans, Male, Middle Aged, Starch, Young Adult",

author = "Mathers, {John C} and Mohammad Movahedi and Finlay Macrae and Jukka-Pekka Mecklin and Gabriela Moeslein and Sylviane Olschwang and Diana Eccles and Gareth Evans and Maher, {Eamonn R} and Lucio Bertario and Bisgaard, {S{\o}s Marie Luise} and Malcolm Dunlop and Ho, {Judy W C} and Shirley Hodgson and Annika Lindblom and Jan Lubinski and Morrison, {Patrick J} and Victoria Murday and Raj Ramesar and Lucy Side and Scott, {Rodney J} and Thomas, {Huw J W} and Hans Vasen and Anne-Marie Gerdes and Gail Barker and Gillian Crawford and Faye Elliott and Kirsi Pylvanainen and Juul Wijnen and Riccardo Fodde and Henry Lynch and Bishop, {D Timothy} and John Burn and {CAPP2 Investigators}",

year = "2012",

doi = "10.1016/S1470-2045(12)70475-8",

language = "English",

volume = "13",

pages = "1242--9",

journal = "Lancet Oncology",

issn = "1470-2045",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer

T2 - an analysis from the CAPP2 randomised controlled trial

AU - Mathers, John C

AU - Movahedi, Mohammad

AU - Macrae, Finlay

AU - Mecklin, Jukka-Pekka

AU - Moeslein, Gabriela

AU - Olschwang, Sylviane

AU - Eccles, Diana

AU - Evans, Gareth

AU - Maher, Eamonn R

AU - Bertario, Lucio

AU - Bisgaard, Søs Marie Luise

AU - Dunlop, Malcolm

AU - Ho, Judy W C

AU - Hodgson, Shirley

AU - Lindblom, Annika

AU - Lubinski, Jan

AU - Morrison, Patrick J

AU - Murday, Victoria

AU - Ramesar, Raj

AU - Side, Lucy

AU - Scott, Rodney J

AU - Thomas, Huw J W

AU - Vasen, Hans

AU - Gerdes, Anne-Marie

AU - Barker, Gail

AU - Crawford, Gillian

AU - Elliott, Faye

AU - Pylvanainen, Kirsi

AU - Wijnen, Juul

AU - Fodde, Riccardo

AU - Lynch, Henry

AU - Bishop, D Timothy

AU - Burn, John

AU - CAPP2 Investigators

PY - 2012

Y1 - 2012

N2 - Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.

AB - Observational studies report that higher intake of dietary fibre (a heterogeneous mix including non-starch polysaccharides and resistant starches) is associated with reduced risk of colorectal cancer, but no randomised trials with prevention of colorectal cancer as a primary endpoint have been done. We assessed the effect of resistant starch on the incidence of colorectal cancer.

KW - Adult

KW - Aged

KW - Colorectal Neoplasms

KW - Colorectal Neoplasms, Hereditary Nonpolyposis

KW - Dietary Carbohydrates

KW - Dietary Fiber

KW - Double-Blind Method

KW - Female

KW - Germ-Line Mutation

KW - Heterozygote

KW - Humans

KW - Male

KW - Middle Aged

KW - Starch

KW - Young Adult

U2 - 10.1016/S1470-2045(12)70475-8

DO - 10.1016/S1470-2045(12)70475-8

M3 - Journal article

C2 - 23140761

SN - 1470-2045

VL - 13

SP - 1242

EP - 1249

JO - Lancet Oncology

JF - Lancet Oncology

IS - 12

ER -

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

Abstract

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