TY - JOUR
T1 - Long-term detection of SARS-CoV-2 antibodies after infection and risk of re-infection
AU - Hønge, Bo Langhoff
AU - Hindhede, Lotte
AU - Kaspersen, Kathrine Agergård
AU - Harritshøj, Lene Holm
AU - Mikkelsen, Susan
AU - Holm, Dorte Kinggaard
AU - Nilsson, Anna Christine
AU - Sækmose, Susanne Gjørup
AU - Sørensen, Erik
AU - Aagaard, Bitten
AU - Hjalgrim, Henrik
AU - Jørgensen, Charlotte Sværke
AU - Krause, Tyra Grove
AU - Ullum, Henrik
AU - Pedersen, Ole Birger Vestager
AU - Ostrowski, Sisse Rye
AU - Erikstrup, Christian
N1 - Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2022/3
Y1 - 2022/3
N2 - OBJECTIVES: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 METHODS: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa).RESULTS: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039-0.262)).CONCLUSION: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.
AB - OBJECTIVES: To evaluate long-term sensitivity for detection of total antibodies against SARS-CoV-2 METHODS: From week 41, 2020, through week 26, 2021, all Danish blood donations were tested for SARS-CoV-2 antibodies with the Wantai assay. The results were linked with polymerase chain reaction (PCR) test results from the Danish Microbiological Database (MiBa).RESULTS: During the study period, 105,646 non-vaccinated Danish blood donors were tested for SARS-CoV-2 antibodies, and 3,806 (3.6%) had a positive PCR test before the blood donation. Among the donors with a positive PCR test, 94.2% subsequently also had a positive antibody test. The time between the positive PCR test and the antibody test was up to 15 months and there was no evidence of a decline in proportion with detectable antibodies over time. A negative serological result test was associated with a higher incidence of re-infection (Incidence Rate Ratio = 0.102 (95% confidence interval (CI): 0.039-0.262)).CONCLUSION: Among healthy blood donors, 94.2% developed SARS-CoV-2 antibodies after infection, and a lack of detectable antibodies was associated with re-infection.
KW - SARS-CoV-2
KW - Wantai
KW - blood donors
KW - sensitivity
KW - seroprevalence
UR - https://www.scopus.com/pages/publications/85124066683
U2 - 10.1016/j.ijid.2022.01.041
DO - 10.1016/j.ijid.2022.01.041
M3 - Journal article
C2 - 35077881
SN - 1201-9712
VL - 116
SP - 289
EP - 292
JO - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ER -