Abstrakt
Accumulation of subcutaneous fat is described in a 51-year-old woman with panhypopituitarism treated on all insufficient pituitary axes, including growth hormone (GH). Malnutrition and alcoholic liver disease caused reduced synthesis of hepatic insulin-like growth factor I (IGF-I), and the function of IGF-I as biochemical marker of the GH effect was compromised. Peripheral levels of GH and IGF-I in tissues may have reached supra physiological levels and induced localised lipohypertrophy. Adjustment of GH treatment should not rest in all cases on IGF-I alone, but also depend on the clinical effect. Adjustment should follow suspected adverse events, such as lipohypertrophy, which is, however, an unusual complication of GH therapy.
Bidragets oversatte titel | Localized lipohypertrophy during growth hormone therapy |
---|---|
Originalsprog | Dansk |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 164 |
Udgave nummer | 14 |
Sider (fra-til) | 1930-2 |
Antal sider | 3 |
ISSN | 0041-5782 |
Status | Udgivet - 1 apr. 2002 |
Emneord
- Adipose Tissue/drug effects
- Female
- Growth Hormone/administration & dosage
- Humans
- Hypertrophy/chemically induced
- Insulin-Like Growth Factor I/metabolism
- Lipodystrophy/chemically induced
- Middle Aged