Lokaliseret lipohypertrophia under behandling med vaeksthormon

Henriette Mersebach, Ulla F Feldt-Rasmussen

Abstrakt

Accumulation of subcutaneous fat is described in a 51-year-old woman with panhypopituitarism treated on all insufficient pituitary axes, including growth hormone (GH). Malnutrition and alcoholic liver disease caused reduced synthesis of hepatic insulin-like growth factor I (IGF-I), and the function of IGF-I as biochemical marker of the GH effect was compromised. Peripheral levels of GH and IGF-I in tissues may have reached supra physiological levels and induced localised lipohypertrophy. Adjustment of GH treatment should not rest in all cases on IGF-I alone, but also depend on the clinical effect. Adjustment should follow suspected adverse events, such as lipohypertrophy, which is, however, an unusual complication of GH therapy.

Bidragets oversatte titelLocalized lipohypertrophy during growth hormone therapy
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind164
Udgave nummer14
Sider (fra-til)1930-2
Antal sider3
ISSN0041-5782
StatusUdgivet - 1 apr. 2002

Emneord

  • Adipose Tissue/drug effects
  • Female
  • Growth Hormone/administration & dosage
  • Humans
  • Hypertrophy/chemically induced
  • Insulin-Like Growth Factor I/metabolism
  • Lipodystrophy/chemically induced
  • Middle Aged

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