Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Liver transplantation for erythropoietic protoporphyria in Europe

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Alterations in gut microbial function following liver transplant

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Percutaneous yttrium aluminum garnet-laser lithotripsy of intrahepatic stones and casts after liver transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The psychological symptom burden in partners of pancreatic cancer patients: a population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Phrenic Nerve Block on Severe Post-Hepatectomy Shoulder Pain: A Randomized, Double-blind, Placebo-controlled, Pilot Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Morbidity and mortality after liver surgery for colorectal liver metastases: a cohort study in a high-volume fast-track programme

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The Danish comorbidity in liver transplant recipients study (DACOLT): a non-interventional prospective observational cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Staffan Wahlin
  • Per Stal
  • Rene Adam
  • Vincent Karam
  • Robert Porte
  • Daniel Seehofer
  • Bridget K Gunson
  • Jens Hillingsø
  • Jürgen L Klempnauer
  • Jan Schmidt
  • Graeme Alexander
  • John O'Grady
  • Pierre-Alain Clavien
  • Mauro Salizzoni
  • Andreas Paul
  • Keith Rolles
  • Bo-Göran Ericzon
  • Pauline Harper
  • European Liver and Intestine Transplant Association
Vis graf over relationer

Liver transplantation is an established lifesaving treatment for patients with severe protoporphyric liver disease, but disease recurrence in the graft occurs for the majority of recipients. Severe burn injuries may occur when protective light filters are not used with surgical luminaires. Motor neuropathy with an unclear pathogenesis is a frequent complication. We retrospectively studied 35 transplants performed for protoporphyric liver disease in 31 European patients between 1983 and 2008. Most of the patients were male (61.3%), and the mean age at the time of primary transplantation was 39 years (range = 9-60 years). The overall patient survival rates were 77% at 1 year and 66% at 5 and 10 years. The overall rate of disease recurrence in the graft was 69%. Forty-three percent of the patients experienced recurrence within a year, but this was often a transient finding that was associated with other graft complications. Phototoxic injuries due to surgical luminaires were seen in 25.0% of the patients who were not protected by filters, but these injuries were not seen in the 9 patients who were protected by filters. Significant motor neuropathies requiring prolonged ventilation complicated the postoperative course for 5 of the 31 patients (16.1%). Hematopoietic stem cell transplantation was performed for 3 patients to prevent graft loss due to disease recurrence. Prognostic markers are needed to identify patients prone to severe protoporphyric liver disease so that curative stem cell transplantation can be offered to select patients instead of liver transplantation.

OriginalsprogEngelsk
TidsskriftLiver Transplantation
Vol/bind17
Udgave nummer9
Sider (fra-til)1021-6
Antal sider6
DOI
StatusUdgivet - sep. 2011

ID: 43992175