Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Liposome accumulation in irradiated tumors display important tumor and dose dependent differences

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Electrochemical sensing of biomarker for diagnostics of bacteria-specific infections

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. David versus Goliath

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. FDG-PET/CT in the surveillance of head and neck cancer following radiotherapy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Surgical Management, Preoperative Tumor Localization, and Histopathology of 80 Patients Operated on for Insulinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.

OriginalsprogEngelsk
TidsskriftNanomedicine
Vol/bind14
Udgave nummer1
Sider (fra-til)27-34
Antal sider8
ISSN1743-5889
DOI
StatusUdgivet - jan. 2018

ID: 52703561