Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

Ronan Mg Berg; Ronni R Plovsing; Kevin A Evans; Claus B Christiansen; Damian M Bailey; Niels-Henrik Holstein-Rathlou; Kirsten Møller

doi:10.1186/cc13062

Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

Ronan Mg Berg, Ronni R Plovsing, Kevin A Evans, Claus B Christiansen, Damian M Bailey, Niels-Henrik Holstein-Rathlou, Kirsten Møller

16 Citationer (Scopus)

Abstract

Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.

Originalsprog	Engelsk
Tidsskrift	Critical Care (Online Edition)
Vol/bind	17
Udgave nummer	5
Sider (fra-til)	R238
ISSN	1466-609X
DOI	https://doi.org/10.1186/cc13062
Status	Udgivet - 16 okt. 2013

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10.1186/cc13062

Citationsformater

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title = "Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers",

abstract = "Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.",

author = "Berg, {Ronan Mg} and Plovsing, {Ronni R} and Evans, {Kevin A} and Christiansen, {Claus B} and Bailey, {Damian M} and Niels-Henrik Holstein-Rathlou and Kirsten M{\o}ller",

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T1 - Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

AU - Berg, Ronan Mg

AU - Plovsing, Ronni R

AU - Evans, Kevin A

AU - Christiansen, Claus B

AU - Bailey, Damian M

AU - Holstein-Rathlou, Niels-Henrik

AU - Møller, Kirsten

PY - 2013/10/16

Y1 - 2013/10/16

N2 - Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.

AB - Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis.

U2 - 10.1186/cc13062

DO - 10.1186/cc13062

M3 - Journal article

C2 - 24131656

SN - 1466-609X

VL - 17

SP - R238

JO - Critical Care (Online Edition)

JF - Critical Care (Online Edition)

IS - 5

ER -

Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

Abstract

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