Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: Are different antiretroviral drugs associated with different lipid profiles?

E. Fontas, F. Van Leth, C. A. Sabin*, N. Friis-Møller, M. Rickenbach, A. D'Arminio Monforte, O. Kirk, M. Dupon, L. Morfeldt, S. Mateu, K. Petoumenos, W. El-Sadr, S. De Wit, J. D. Lundgren, C. Pradier, P. Reiss

*Corresponding author af dette arbejde
303 Citationer (Scopus)

Abstract

Levek of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c), as well as the TC:HDL-c ratio, were compared in patients receiving different antiretroviral therapy regimens. Patients receiving first-line regimens including protease inhibitors (PIs) had higher TC and TG levels and TC:HDL-c ratios than did antiretroviral-naive patients; patients receiving 2 PIs had higher levels of each lipid. Ritonavir-containing regimens were associated with higher TC and TG levels and TC:HDL-c ratios than were indinavir-containing regimens; however, receipt of nelfinavir was associated with reduced risk of lower HDL-c levels, and receipt of saquinavir was associated with lower TC: HDL-c ratios. Patients receiving non-nucleoside reverse-transcriptase inhibitors had higher levels of TC and LDL-c than did antiretroviral-naive patients, although the risk of having lower HDL-c levels was lower than that in patients receiving a single PI. Efavirenz was associated with higher levels of TC and TG than was nevirapine.

OriginalsprogEngelsk
TidsskriftJournal of Infectious Diseases
Vol/bind189
Udgave nummer6
Sider (fra-til)1056-1074
Antal sider19
ISSN0022-1899
DOI
StatusUdgivet - 15 mar. 2004
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: Are different antiretroviral drugs associated with different lipid profiles?'. Sammen danner de et unikt fingeraftryk.

Citationsformater