Linkage between the loci for cystic fibrosis and paraoxonase

K Schmiegelow; H Eiberg; L C Tsui; M Buchwald; P D Phelan; R Williamson; W Warwick; E Niebuhr; J Mohr; M Schwartz

doi:10.1111/j.1399-0004.1986.tb00507.x

Linkage between the loci for cystic fibrosis and paraoxonase

K Schmiegelow, H Eiberg, L C Tsui, M Buchwald, P D Phelan, R Williamson, W Warwick, E Niebuhr, J Mohr, M Schwartz

14 Citationer (Scopus)

Abstract

In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis-paraoxonase (PON) at recombination fraction theta = 0.07 in males and theta = 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF-PON synteny.

Originalsprog	Engelsk
Tidsskrift	Clinical Genetics
Vol/bind	29
Udgave nummer	5
Sider (fra-til)	374-7
Antal sider	4
ISSN	0009-9163
DOI	https://doi.org/10.1111/j.1399-0004.1986.tb00507.x
Status	Udgivet - maj 1986
Udgivet eksternt	Ja

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10.1111/j.1399-0004.1986.tb00507.x

Citationsformater

@article{748e4682a4c54d2bbc8713fc8cbed40a,

title = "Linkage between the loci for cystic fibrosis and paraoxonase",

abstract = "In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis-paraoxonase (PON) at recombination fraction theta = 0.07 in males and theta = 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF-PON synteny.",

keywords = "Alleles, Aryldialkylphosphatase, Cystic Fibrosis/enzymology, Female, Genetic Linkage, Genetic Markers, Humans, Lod Score, Male, Models, Genetic, Phosphoric Monoester Hydrolases/genetics",

author = "K Schmiegelow and H Eiberg and Tsui, {L C} and M Buchwald and Phelan, {P D} and R Williamson and W Warwick and E Niebuhr and J Mohr and M Schwartz",

year = "1986",

month = may,

doi = "10.1111/j.1399-0004.1986.tb00507.x",

language = "English",

volume = "29",

pages = "374--7",

journal = "Clinical Genetics",

issn = "0009-9163",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Linkage between the loci for cystic fibrosis and paraoxonase

AU - Schmiegelow, K

AU - Eiberg, H

AU - Tsui, L C

AU - Buchwald, M

AU - Phelan, P D

AU - Williamson, R

AU - Warwick, W

AU - Niebuhr, E

AU - Mohr, J

AU - Schwartz, M

PY - 1986/5

Y1 - 1986/5

N2 - In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis-paraoxonase (PON) at recombination fraction theta = 0.07 in males and theta = 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF-PON synteny.

AB - In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis-paraoxonase (PON) at recombination fraction theta = 0.07 in males and theta = 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF-PON synteny.

KW - Alleles

KW - Aryldialkylphosphatase

KW - Cystic Fibrosis/enzymology

KW - Female

KW - Genetic Linkage

KW - Genetic Markers

KW - Humans

KW - Lod Score

KW - Male

KW - Models, Genetic

KW - Phosphoric Monoester Hydrolases/genetics

U2 - 10.1111/j.1399-0004.1986.tb00507.x

DO - 10.1111/j.1399-0004.1986.tb00507.x

M3 - Journal article

C2 - 3017612

SN - 0009-9163

VL - 29

SP - 374

EP - 377

JO - Clinical Genetics

JF - Clinical Genetics

IS - 5

ER -

Linkage between the loci for cystic fibrosis and paraoxonase

Abstract

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