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Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men

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Redd, AD, Helleberg, M, Sievers, M, Schmidt, SD, Doria-Rose, NA, Bruno, D, Traeger, S, Martens, C, Fonager, J, Kronborg, G, Packman, Z, Mascola, JR, Porcella, SF, Gerstoft, J & Quinn, TC 2019, 'Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men' Infectious Diseases, bind 51, nr. 1, s. 56-61. https://doi.org/10.1080/23744235.2018.1500708

APA

CBE

Redd AD, Helleberg M, Sievers M, Schmidt SD, Doria-Rose NA, Bruno D, Traeger S, Martens C, Fonager J, Kronborg G, Packman Z, Mascola JR, Porcella SF, Gerstoft J, Quinn TC. 2019. Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men. Infectious Diseases. 51(1):56-61. https://doi.org/10.1080/23744235.2018.1500708

MLA

Vancouver

Author

Redd, Andrew D ; Helleberg, Marie ; Sievers, Matthew ; Schmidt, Stephen D ; Doria-Rose, Nicole A ; Bruno, Daniel ; Traeger, Shelby ; Martens, Craig ; Fonager, Jannik ; Kronborg, Gitte ; Packman, Zoe ; Mascola, John R ; Porcella, Stephen F ; Gerstoft, Jan ; Quinn, Thomas C. / Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men. I: Infectious Diseases. 2019 ; Bind 51, Nr. 1. s. 56-61.

Bibtex

@article{b3bd8c8af60e4b909689643aeab835d3,
title = "Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men",
abstract = "BACKGROUND: The role of the anti-HIV neutralizing antibody response in protecting against HIV superinfection, and changes in neutralizing antibody potency and breadth after HIV superinfection have not been fully elucidated. This study examined the rate of HIV superinfection in men who have sex with men (MSM) also diagnosed with syphilis in Denmark, and the anti-HIV neutralizing antibody response in men who became superinfected.MATERIALS AND METHODS: MSM enrolled in the Danish HIV cohort who acquired syphilis were examined longitudinally for HIV superinfection using a validated next-generation sequencing assay. HIV superinfection cases were matched 3:1 to controls, and neutralizing antibody responses before (cases/controls) and after (cases) HIV superinfection were determined using a 20-pseudovirus panel.RESULTS: Four cases of HIV superinfection were identified from 95 MSM screened for a rate of HIV superinfection of 1.56/100 pys (95{\%} CI = 0.43-4.01). Prior to HIV superinfection neutralizing antibody responses were low in breadth and potency, and did not differ between cases and controls (p = 1.0). In cases, neutralizing antibody responses increased modestly after HIV superinfection.CONCLUSIONS: These data support the theory that the natural neutralizing antibody response to HIV infection may not be the controlling factor in protecting against a subsequent HIV challenge.",
author = "Redd, {Andrew D} and Marie Helleberg and Matthew Sievers and Schmidt, {Stephen D} and Doria-Rose, {Nicole A} and Daniel Bruno and Shelby Traeger and Craig Martens and Jannik Fonager and Gitte Kronborg and Zoe Packman and Mascola, {John R} and Porcella, {Stephen F} and Jan Gerstoft and Quinn, {Thomas C}",
year = "2019",
month = "1",
doi = "10.1080/23744235.2018.1500708",
language = "English",
volume = "51",
pages = "56--61",
journal = "Infectious Diseases",
issn = "2374-4235",
publisher = "Taylor and Francis Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men

AU - Redd, Andrew D

AU - Helleberg, Marie

AU - Sievers, Matthew

AU - Schmidt, Stephen D

AU - Doria-Rose, Nicole A

AU - Bruno, Daniel

AU - Traeger, Shelby

AU - Martens, Craig

AU - Fonager, Jannik

AU - Kronborg, Gitte

AU - Packman, Zoe

AU - Mascola, John R

AU - Porcella, Stephen F

AU - Gerstoft, Jan

AU - Quinn, Thomas C

PY - 2019/1

Y1 - 2019/1

N2 - BACKGROUND: The role of the anti-HIV neutralizing antibody response in protecting against HIV superinfection, and changes in neutralizing antibody potency and breadth after HIV superinfection have not been fully elucidated. This study examined the rate of HIV superinfection in men who have sex with men (MSM) also diagnosed with syphilis in Denmark, and the anti-HIV neutralizing antibody response in men who became superinfected.MATERIALS AND METHODS: MSM enrolled in the Danish HIV cohort who acquired syphilis were examined longitudinally for HIV superinfection using a validated next-generation sequencing assay. HIV superinfection cases were matched 3:1 to controls, and neutralizing antibody responses before (cases/controls) and after (cases) HIV superinfection were determined using a 20-pseudovirus panel.RESULTS: Four cases of HIV superinfection were identified from 95 MSM screened for a rate of HIV superinfection of 1.56/100 pys (95% CI = 0.43-4.01). Prior to HIV superinfection neutralizing antibody responses were low in breadth and potency, and did not differ between cases and controls (p = 1.0). In cases, neutralizing antibody responses increased modestly after HIV superinfection.CONCLUSIONS: These data support the theory that the natural neutralizing antibody response to HIV infection may not be the controlling factor in protecting against a subsequent HIV challenge.

AB - BACKGROUND: The role of the anti-HIV neutralizing antibody response in protecting against HIV superinfection, and changes in neutralizing antibody potency and breadth after HIV superinfection have not been fully elucidated. This study examined the rate of HIV superinfection in men who have sex with men (MSM) also diagnosed with syphilis in Denmark, and the anti-HIV neutralizing antibody response in men who became superinfected.MATERIALS AND METHODS: MSM enrolled in the Danish HIV cohort who acquired syphilis were examined longitudinally for HIV superinfection using a validated next-generation sequencing assay. HIV superinfection cases were matched 3:1 to controls, and neutralizing antibody responses before (cases/controls) and after (cases) HIV superinfection were determined using a 20-pseudovirus panel.RESULTS: Four cases of HIV superinfection were identified from 95 MSM screened for a rate of HIV superinfection of 1.56/100 pys (95% CI = 0.43-4.01). Prior to HIV superinfection neutralizing antibody responses were low in breadth and potency, and did not differ between cases and controls (p = 1.0). In cases, neutralizing antibody responses increased modestly after HIV superinfection.CONCLUSIONS: These data support the theory that the natural neutralizing antibody response to HIV infection may not be the controlling factor in protecting against a subsequent HIV challenge.

UR - http://www.scopus.com/inward/record.url?scp=85054915923&partnerID=8YFLogxK

U2 - 10.1080/23744235.2018.1500708

DO - 10.1080/23744235.2018.1500708

M3 - Journal article

VL - 51

SP - 56

EP - 61

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 1

ER -

ID: 55449774