Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

Mads Hornum; Klaus Leth Mortensen; Anne-Lise Kamper; Ase Bengård Andersen

doi:10.1016/j.ejim.2007.03.020

Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

13 Citationer (Scopus)

Abstract

Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.

Originalsprog	Engelsk
Tidsskrift	European Journal of Internal Medicine
Vol/bind	19
Udgave nummer	2
Sider (fra-til)	137-9
Antal sider	3
ISSN	0953-6205
DOI	https://doi.org/10.1016/j.ejim.2007.03.020
Status	Udgivet - mar. 2008

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10.1016/j.ejim.2007.03.020

Citationsformater

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title = "Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients",

abstract = "Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.",

keywords = "False Negative Reactions, Female, Humans, Immunocompromised Host, Male, Middle Aged, Mycobacterium tuberculosis, Sensitivity and Specificity, Tuberculosis, Pulmonary",

author = "Mads Hornum and Mortensen, \{Klaus Leth\} and Anne-Lise Kamper and Andersen, \{Ase Beng{\aa}rd\}",

year = "2008",

month = mar,

doi = "10.1016/j.ejim.2007.03.020",

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volume = "19",

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TY - JOUR

T1 - Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

AU - Hornum, Mads

AU - Mortensen, Klaus Leth

AU - Kamper, Anne-Lise

AU - Andersen, Ase Bengård

PY - 2008/3

Y1 - 2008/3

N2 - Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.

AB - Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.

KW - False Negative Reactions

KW - Female

KW - Humans

KW - Immunocompromised Host

KW - Male

KW - Middle Aged

KW - Mycobacterium tuberculosis

KW - Sensitivity and Specificity

KW - Tuberculosis, Pulmonary

U2 - 10.1016/j.ejim.2007.03.020

DO - 10.1016/j.ejim.2007.03.020

M3 - Journal article

C2 - 18249311

SN - 0953-6205

VL - 19

SP - 137

EP - 139

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

IS - 2

ER -

Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

Abstract

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