TY - JOUR
T1 - Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients
AU - Hornum, Mads
AU - Mortensen, Klaus Leth
AU - Kamper, Anne-Lise
AU - Andersen, Ase Bengård
PY - 2008/3
Y1 - 2008/3
N2 - Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.
AB - Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.
KW - False Negative Reactions
KW - Female
KW - Humans
KW - Immunocompromised Host
KW - Male
KW - Middle Aged
KW - Mycobacterium tuberculosis
KW - Sensitivity and Specificity
KW - Tuberculosis, Pulmonary
U2 - 10.1016/j.ejim.2007.03.020
DO - 10.1016/j.ejim.2007.03.020
M3 - Journal article
C2 - 18249311
SN - 0953-6205
VL - 19
SP - 137
EP - 139
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
IS - 2
ER -