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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders

Publikation: Bidrag til tidsskriftReviewpeer review

  1. TDP-43-specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  • Jennifer S Graves
  • Frederike Cosima Oertel
  • Anneke Van der Walt
  • Sara Collorone
  • Elias S Sotirchos
  • Gorm Pihl-Jensen
  • Philipp Albrecht
  • E Ann Yeh
  • Shiv Saidha
  • Jette Frederiksen
  • Scott Douglas Newsome
  • Friedemann Paul
  • IMSVISUAL
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The visual system offers unparalleled precision in the assessment of neuroaxonal damage. With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent visual dysfunction, outcome measures capturing these deficits provide insight into neuroaxonal injury, even in those with minimal disability. Ideal for use in clinical trials, visual measures are generally inexpensive, accessible, and reproducible. Quantification of visual acuity, visual fields, visual quality of life, and electrophysiologic parameters allows assessment of function, whereas optical coherence tomography (OCT) provides reliable measures of the structural integrity of the anterior afferent visual pathway. The technology of oculomotor biometrics continues to advance, and discrete measures of fixation, smooth pursuit, and saccadic eye movement abnormalities are ready for inclusion in future trials of MS progression. Visual outcomes allow tracking of neuroaxonal injury and aid in distinguishing MS from diseases such as neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein antibody-associated diseases (MOGAD). OCT has also provided unique insights into pathophysiology, including the identification of foveal pitting in NMOSD, possibly from damage to Müller cells, which carry an abundance of aquaporin-4 channels. For some study designs, the cost-benefit ratio favors visual outcomes over more expensive MRI outcomes. With the next frontier of therapeutics focused on remyelination and neuroprotection, visual outcomes are likely to take center stage. As an international community of collaborative, committed, vision scientists, this review by the International MS Visual System Consortium (IMSVISUAL) outlines the quality standards, informatics, and framework needed to routinely incorporate vision outcomes into MS and NMOSD trials.

OriginalsprogEngelsk
TidsskriftNeurology: Neuroimmunology and NeuroInflammation
Vol/bind9
Udgave nummer2
Sider (fra-til)e1126
Antal sider17
ISSN2332-7812
DOI
StatusUdgivet - mar. 2022

Bibliografisk note

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

ID: 72897642