Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Levels of SARS-CoV-2 antibodies among fully vaccinated individuals with Delta or Omicron variant breakthrough infections

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Serum metabolome associated with severity of acute traumatic brain injury

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  1. A randomized placebo-controlled trial of convalescent plasma for adults hospitalized with COVID-19 pneumonia

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19: A Randomized Controlled Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Lipoprotein(a) during COVID-19 hospitalization: Thrombosis, inflammation, and mortality

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. SARS-CoV-2 Surface Swabs in Locations With Public Access-Potential for Improved Source Control

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk of breakthrough infection in a fully vaccinated cohort. SARS-CoV-2 anti-spike IgG levels were measured before first SARS-CoV-2 vaccination and at day 21-28, 90 and 180, as well as after booster vaccination. Breakthrough infections were captured through the Danish National Microbiology database. incidence rate ratio (IRR) for breakthrough infection at time-updated anti-spike IgG levels was determined using Poisson regression. Among 6076 participants, 127 and 364 breakthrough infections due to Delta and Omicron variants were observed. IRR was 0.29 (95% CI 0.15-0.56) for breakthrough infection with the Delta variant, comparing the highest and lowest quintiles of anti-spike IgG. For Omicron, no significant differences in IRR were observed. These results suggest that quantitative level of anti-spike IgG have limited impact on the risk of breakthrough infection with Omicron.

OriginalsprogEngelsk
Artikelnummer4466
TidsskriftNature Communications
Vol/bind13
Udgave nummer1
Sider (fra-til)1-8
Antal sider8
ISSN2041-1722
DOI
StatusUdgivet - 1 aug. 2022

Bibliografisk note

© 2022. The Author(s).

ID: 79862367