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Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

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@article{a6dd1bccc6f4493a8e9977fbbc3568e7,
title = "Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures",
abstract = "Brain cancer stem-like cells (bCSC) are cancer cells with neural stem cell (NSC)-like properties found in glioblastoma multiforme (GBM) and they are assigned a central role in tumor initiation, progression and relapse. The Notch pathway is important for maintenance and cell fate decisions in the normal NSC population. Notch signaling is often deregulated in GBM and recent results suggest that this pathway plays a significant role in bCSC as well. We therefore wished to further elucidate the role of Notch activation in GBM-derived bCSC.",
author = "Karina Kristoffersen and Mette Villingsh{\o}j and Poulsen, {Hans Skovgaard} and Marie-Th{\'e}r{\'e}se Stockhausen",
year = "2013",
month = "7",
doi = "10.4161/cbt.24595",
language = "English",
volume = "14",
pages = "625--37",
journal = "Cancer Biology and Therapy",
issn = "1538-4047",
publisher = "Landes Bioscience",
number = "7",

}

RIS

TY - JOUR

T1 - Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

AU - Kristoffersen, Karina

AU - Villingshøj, Mette

AU - Poulsen, Hans Skovgaard

AU - Stockhausen, Marie-Thérése

PY - 2013/7

Y1 - 2013/7

N2 - Brain cancer stem-like cells (bCSC) are cancer cells with neural stem cell (NSC)-like properties found in glioblastoma multiforme (GBM) and they are assigned a central role in tumor initiation, progression and relapse. The Notch pathway is important for maintenance and cell fate decisions in the normal NSC population. Notch signaling is often deregulated in GBM and recent results suggest that this pathway plays a significant role in bCSC as well. We therefore wished to further elucidate the role of Notch activation in GBM-derived bCSC.

AB - Brain cancer stem-like cells (bCSC) are cancer cells with neural stem cell (NSC)-like properties found in glioblastoma multiforme (GBM) and they are assigned a central role in tumor initiation, progression and relapse. The Notch pathway is important for maintenance and cell fate decisions in the normal NSC population. Notch signaling is often deregulated in GBM and recent results suggest that this pathway plays a significant role in bCSC as well. We therefore wished to further elucidate the role of Notch activation in GBM-derived bCSC.

U2 - 10.4161/cbt.24595

DO - 10.4161/cbt.24595

M3 - Journal article

VL - 14

SP - 625

EP - 637

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

SN - 1538-4047

IS - 7

ER -

ID: 42485188