Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Lesion size in relation to ablation site during radiofrequency ablation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Late potentials and their correlation with ventricular structure in patients with ventricular arrhythmias

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The electromechanical substrate for response to cardiac resynchronization therapy in patients with right bundle branch block

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Study Design and Cohort Description of DEFIB-WOMEN: A National Danish Study in Patients with an ICD

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Attitudes toward Catheter Ablation for Atrial Fibrillation: A Nationwide Survey among Danish Cardiologists

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Defibrillators for prevention from sudden cardiac death: is it that easy?-Authors' reply

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

This study was designed to investigate the effect of the convective cooling of the tip of the ablation electrode during temperature controlled radiofrequency ablation. In vivo two different application sites in the left ventricle of anaesthetised pigs were ablated and in vitro ablation was performed during two different flow-velocities in a tissue bath, while electrode contact pressure and position were unchanged. Target temperature was 80 degrees C. Obtained tip temperature, power consumption and lesion dimensions were measured. In vivo lesion volume, depth and width were found significantly larger for septal applications than apical applications (p < 0.01) and more power was used (p < 0.001). Obtained tip temperature was significantly lower in the septal applications (p < 0.001). In vitro increased convective cooling by induction of flow yielded larger lesion volume, depth and width (p < 0.01), and had higher power consumptions (p < 0.01). Obtained tip temperature did not differ significantly. For the given chosen target temperature power consumption was positively related to lesion volume (r = 0.66 in vivo and 0.65 in vitro), whereas obtained tip temperature was not (r = -0.49 in vivo and -0.61 in vitro). We conclude that during temperature controlled radiofrequency ablation lesion size differs for septal and apical left ventricular applications. Differences in convective cooling might play an important role in this respect. This is supported by our in vitro experiments, where increased convective cooling by induction of a flow around the electrode tip increases lesion dimensions and power consumptions. Furthermore we conclude that for the given target temperature the power consumption is positively correlated with lesion volume (p < 0.001), whereas the obtained tip temperature is not.

OriginalsprogEngelsk
TidsskriftPacing and clinical electrophysiology : PACE
Vol/bind21
Udgave nummer1 Pt 2
Sider (fra-til)322-6
Antal sider5
ISSN0147-8389
StatusUdgivet - jan. 1998

ID: 51663846