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Left ventricular systolic ejection time is an independent predictor of all-cause mortality in heart failure with reduced ejection fraction

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@article{dc819792c9c24bf5a40a59d675be02af,
title = "Left ventricular systolic ejection time is an independent predictor of all-cause mortality in heart failure with reduced ejection fraction",
abstract = "AIMS: Colour tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise method to obtain cardiac time intervals including isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT) and systolic ejection time (SET). The myocardial performance index (MPI) is defined as [(IVCT + IVRT)/SET]. Whether cardiac time intervals obtained by the TDI M-mode method can be used to predict outcome in patients with heart failure with reduced ejection fraction (HFrEF) remains unknown.METHODS AND RESULTS: A total of 997 patients with HFrEF (mean age 67 ± 11 years, 74% male) underwent an echocardiographic examination including TDI. During a median follow-up of 3.4 years (interquartile range 1.9-4.8 years), 165 (17%) patients died. The risk of mortality increased by 9% per 10 ms decrease in SET [per 10 ms decrease: hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.06-1.13; P < 0.001]. The association remained significant even after multivariable adjustment for clinical and echocardiographic parameters (per 10 ms decrease: HR 1.06, 95% CI 1.01-1.11; P = 0.030). The MPI was a significant predictor in an unadjusted model (per 0.1 increase: HR 3.06, 95% CI 1.16-8.06; P = 0.023). However, the association did not remain significant after multivariable adjustment. No significant associations between IVCT or IVRT and mortality were found in unadjusted nor adjusted models. Additionally, SET provided incremental prognostic information with regard to predicting mortality when added to established clinical predictors of mortality in patients with HFrEF.CONCLUSION: In patients with HFrEF, SET provides independent and incremental prognostic information regarding all-cause mortality.",
keywords = "Cardiac time intervals, Heart failure, Mortality, Tissue Doppler echocardiography",
author = "Alhakak, {Alia S} and Morten Sengel{\o}v and J{\o}rgensen, {Peter G} and Bruun, {Niels E} and Cecilie Johnsen and Ulrik Abildgaard and Iversen, {Allan Z} and Hansen, {Thomas F} and Teerlink, {John R} and Malik, {Fady I} and Solomon, {Scott D} and Gunnar Gislason and Tor Biering-S{\o}rensen",
note = "{\textcopyright} 2020 European Society of Cardiology.",
year = "2021",
month = feb,
doi = "10.1002/ejhf.2022",
language = "English",
volume = "23",
pages = "240--249",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Wiley",
number = "2",

}

RIS

TY - JOUR

T1 - Left ventricular systolic ejection time is an independent predictor of all-cause mortality in heart failure with reduced ejection fraction

AU - Alhakak, Alia S

AU - Sengeløv, Morten

AU - Jørgensen, Peter G

AU - Bruun, Niels E

AU - Johnsen, Cecilie

AU - Abildgaard, Ulrik

AU - Iversen, Allan Z

AU - Hansen, Thomas F

AU - Teerlink, John R

AU - Malik, Fady I

AU - Solomon, Scott D

AU - Gislason, Gunnar

AU - Biering-Sørensen, Tor

N1 - © 2020 European Society of Cardiology.

PY - 2021/2

Y1 - 2021/2

N2 - AIMS: Colour tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise method to obtain cardiac time intervals including isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT) and systolic ejection time (SET). The myocardial performance index (MPI) is defined as [(IVCT + IVRT)/SET]. Whether cardiac time intervals obtained by the TDI M-mode method can be used to predict outcome in patients with heart failure with reduced ejection fraction (HFrEF) remains unknown.METHODS AND RESULTS: A total of 997 patients with HFrEF (mean age 67 ± 11 years, 74% male) underwent an echocardiographic examination including TDI. During a median follow-up of 3.4 years (interquartile range 1.9-4.8 years), 165 (17%) patients died. The risk of mortality increased by 9% per 10 ms decrease in SET [per 10 ms decrease: hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.06-1.13; P < 0.001]. The association remained significant even after multivariable adjustment for clinical and echocardiographic parameters (per 10 ms decrease: HR 1.06, 95% CI 1.01-1.11; P = 0.030). The MPI was a significant predictor in an unadjusted model (per 0.1 increase: HR 3.06, 95% CI 1.16-8.06; P = 0.023). However, the association did not remain significant after multivariable adjustment. No significant associations between IVCT or IVRT and mortality were found in unadjusted nor adjusted models. Additionally, SET provided incremental prognostic information with regard to predicting mortality when added to established clinical predictors of mortality in patients with HFrEF.CONCLUSION: In patients with HFrEF, SET provides independent and incremental prognostic information regarding all-cause mortality.

AB - AIMS: Colour tissue Doppler imaging (TDI) M-mode through the mitral leaflet is an easy and precise method to obtain cardiac time intervals including isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT) and systolic ejection time (SET). The myocardial performance index (MPI) is defined as [(IVCT + IVRT)/SET]. Whether cardiac time intervals obtained by the TDI M-mode method can be used to predict outcome in patients with heart failure with reduced ejection fraction (HFrEF) remains unknown.METHODS AND RESULTS: A total of 997 patients with HFrEF (mean age 67 ± 11 years, 74% male) underwent an echocardiographic examination including TDI. During a median follow-up of 3.4 years (interquartile range 1.9-4.8 years), 165 (17%) patients died. The risk of mortality increased by 9% per 10 ms decrease in SET [per 10 ms decrease: hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.06-1.13; P < 0.001]. The association remained significant even after multivariable adjustment for clinical and echocardiographic parameters (per 10 ms decrease: HR 1.06, 95% CI 1.01-1.11; P = 0.030). The MPI was a significant predictor in an unadjusted model (per 0.1 increase: HR 3.06, 95% CI 1.16-8.06; P = 0.023). However, the association did not remain significant after multivariable adjustment. No significant associations between IVCT or IVRT and mortality were found in unadjusted nor adjusted models. Additionally, SET provided incremental prognostic information with regard to predicting mortality when added to established clinical predictors of mortality in patients with HFrEF.CONCLUSION: In patients with HFrEF, SET provides independent and incremental prognostic information regarding all-cause mortality.

KW - Cardiac time intervals

KW - Heart failure

KW - Mortality

KW - Tissue Doppler echocardiography

UR - http://www.scopus.com/inward/record.url?scp=85093826873&partnerID=8YFLogxK

U2 - 10.1002/ejhf.2022

DO - 10.1002/ejhf.2022

M3 - Journal article

C2 - 33034122

VL - 23

SP - 240

EP - 249

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 2

ER -

ID: 65850880