Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Left ventricular end-diastolic pressure is associated with left atrial functional measures by echocardiography

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

DOI

  1. Incidence rates of dilated cardiomyopathy in adult first-degree relatives versus matched controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  2. Left atrial contractile strain predicts recurrence of atrial tachyarrhythmia after catheter ablation

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  3. Risk of out-of-hospital cardiac arrest in antidepressant drug users

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  4. Workforce attachment after a congenital long QT syndrome diagnosis: a Danish nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

Vis graf over relationer

Echocardiography guidelines recommend the assessment of maximal LA volume (LAVmax). Evidence, however, suggests additional value of functional LA measures. We investigated the association between functional LA measures and left ventricular end-diastolic pressure (LVEDP). Patients suspected of coronary artery disease referred for invasive coronary angiography (ICA) underwent, in addition to ICA, invasive pressure measurements. LVEDP > 12 mmHg was considered elevated. LA measurements by echocardiography included: LAVmax, minimal LA volume (LAVmin), total LA emptying fraction (LAEFtotal), passive LA emptying fraction (LAEFpassive), and active LA emptying fraction (LAEFactive). Of 43 patients, 28 (65%) had elevated LVEDP. These patients more frequently had coronary vessel disease (VD) and impaired LA mechanics for all measures except LAVmax. All LA measures except LAVmax were associated with LVEDP in unadjusted linear regression analyses. After adjustment for age and VD, only LA emptying fractions remained associated with LVEDP (2.6 (1.2-4.0) mmHg increase, p = 0.001, per 5% decrease in LAEFtotal; 1.4 (0.1-2.8) mmHg increase, p = 0.040, per 5% decrease in LAEFactive; 1.8 (0.1-3.4) mmHg increase, p = 0.038, per 5% decrease in LAEFpassive). In logistic regression, only LAEFpassive was significantly associated with elevated LVEDP after adjusting for age and VD (OR = 1.11 (1.01-1.21), p = 0.023, per 1% decrease). Similar findings were made in subgroup analyses among patients without dilated LA and patients without conventional indicators of elevated filling pressure. Left ventricular end-diastolic pressure is significantly associated with LA functional measures but not LA volumes. Additionally, LAEFpassive is associated with elevated LVEDP. Future studies examining LA function should include all components of LAEF.

OriginalsprogEngelsk
TidsskriftThe international journal of cardiovascular imaging
Vol/bind37
Udgave nummer11
Sider (fra-til)3213-3221
Antal sider9
ISSN1569-5794
DOI
StatusUdgivet - nov. 2021

Bibliografisk note

© 2021. The Author(s), under exclusive licence to Springer Nature B.V.

ID: 69610609