Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial

K F Kofoed; H Kelbæk; L Thuesen; S H Poulsen; C Hassager; N H Andersen; S Helqvist; J F Lassen; P Clemmensen; L Kløvgaard; A Kaltoft; T Engstrøm; L R Krusell; C J Terkelsen; L Køber

doi:10.1016/j.ijcard.2009.07.020

Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial

K F Kofoed, H Kelbæk, L Thuesen, S H Poulsen, C Hassager, N H Andersen, S Helqvist, J F Lassen, P Clemmensen, L Kløvgaard, A Kaltoft, T Engstrøm, L R Krusell, C J Terkelsen, L Køber

3 Citationer (Scopus)

Abstract

BACKGROUND: Coronary intervention (PCI) may result in an increased infarct size. We evaluated the effect of distal protection during PCI for ST-segment elevation myocardial infarction (STEMI) on myocardial function.

METHODS: Patients with STEMI were randomly referred within 12 h for PCI with (N = 312) or without distal protection (N = 314). Left ventricular (LV) contractile function was assessed with echocardiography 8 months after PCI. Global LV myocardial wall motion index (WMI) was calculated as the average wall motion score of all myocardial segments. The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI were also recorded.

RESULTS: The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI was 7.1% after distal protection and 5.7% after conventional treatment (p = 0.17). WMI improved by 4.1% at 8 months in patients treated with distal protection compared to patients receiving conventional PCI (p < 0.01). In myocardium supplied by a culprit artery treated by distal protection regional LV function was 9-11% higher than myocardial regions treated conventionally ( p < 0.02).

CONCLUSIONS: Routine use of distal protection during primary PCI is associated with a significant improvement in LV contractile function, with no detectable impact on intermediate term clinical outcome.

Originalsprog	Engelsk
Tidsskrift	International Journal of Cardiology
Vol/bind	146
Udgave nummer	3
Sider (fra-til)	395-8
Antal sider	4
ISSN	0167-5273
DOI	https://doi.org/10.1016/j.ijcard.2009.07.020
Status	Udgivet - 3 feb. 2011
Udgivet eksternt	Ja

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10.1016/j.ijcard.2009.07.020

Citationsformater

Kofoed, K. F., Kelbæk, H., Thuesen, L., Poulsen, S. H., Hassager, C., Andersen, N. H., Helqvist, S., Lassen, J. F., Clemmensen, P., Kløvgaard, L., Kaltoft, A., Engstrøm, T., Krusell, L. R., Terkelsen, C. J., & Køber, L. (2011). Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial. International Journal of Cardiology, 146(3), 395-8. https://doi.org/10.1016/j.ijcard.2009.07.020

Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial. / Kofoed, K F; Kelbæk, H; Thuesen, L et al.
I: International Journal of Cardiology, Bind 146, Nr. 3, 03.02.2011, s. 395-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Kofoed, KF, Kelbæk, H, Thuesen, L, Poulsen, SH, Hassager, C, Andersen, NH, Helqvist, S, Lassen, JF, Clemmensen, P, Kløvgaard, L, Kaltoft, A, Engstrøm, T, Krusell, LR, Terkelsen, CJ & Køber, L 2011, 'Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial', International Journal of Cardiology, bind 146, nr. 3, s. 395-8. https://doi.org/10.1016/j.ijcard.2009.07.020

Kofoed KF, Kelbæk H, Thuesen L, Poulsen SH, Hassager C, Andersen NH et al. Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial. International Journal of Cardiology. 2011 feb. 3;146(3):395-8. doi: 10.1016/j.ijcard.2009.07.020

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title = "Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial",

abstract = "BACKGROUND: Coronary intervention (PCI) may result in an increased infarct size. We evaluated the effect of distal protection during PCI for ST-segment elevation myocardial infarction (STEMI) on myocardial function.METHODS: Patients with STEMI were randomly referred within 12 h for PCI with (N = 312) or without distal protection (N = 314). Left ventricular (LV) contractile function was assessed with echocardiography 8 months after PCI. Global LV myocardial wall motion index (WMI) was calculated as the average wall motion score of all myocardial segments. The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI were also recorded.RESULTS: The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI was 7.1% after distal protection and 5.7% after conventional treatment (p = 0.17). WMI improved by 4.1% at 8 months in patients treated with distal protection compared to patients receiving conventional PCI (p < 0.01). In myocardium supplied by a culprit artery treated by distal protection regional LV function was 9-11% higher than myocardial regions treated conventionally ( p < 0.02).CONCLUSIONS: Routine use of distal protection during primary PCI is associated with a significant improvement in LV contractile function, with no detectable impact on intermediate term clinical outcome.",

keywords = "Angioplasty, Balloon, Coronary/methods, Humans, Myocardial Contraction, Myocardial Infarction/physiopathology, Postoperative Complications/prevention & control, Ventricular Function, Left",

author = "Kofoed, {K F} and H Kelb{\ae}k and L Thuesen and Poulsen, {S H} and C Hassager and Andersen, {N H} and S Helqvist and Lassen, {J F} and P Clemmensen and L Kl{\o}vgaard and A Kaltoft and T Engstr{\o}m and Krusell, {L R} and Terkelsen, {C J} and L K{\o}ber",

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doi = "10.1016/j.ijcard.2009.07.020",

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T1 - Left ventricular contractile function after distal protection in primary percutaneous coronary intervention

T2 - results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial

AU - Kofoed, K F

AU - Kelbæk, H

AU - Thuesen, L

AU - Poulsen, S H

AU - Hassager, C

AU - Andersen, N H

AU - Helqvist, S

AU - Lassen, J F

AU - Clemmensen, P

AU - Kløvgaard, L

AU - Kaltoft, A

AU - Engstrøm, T

AU - Krusell, L R

AU - Terkelsen, C J

AU - Køber, L

PY - 2011/2/3

Y1 - 2011/2/3

N2 - BACKGROUND: Coronary intervention (PCI) may result in an increased infarct size. We evaluated the effect of distal protection during PCI for ST-segment elevation myocardial infarction (STEMI) on myocardial function.METHODS: Patients with STEMI were randomly referred within 12 h for PCI with (N = 312) or without distal protection (N = 314). Left ventricular (LV) contractile function was assessed with echocardiography 8 months after PCI. Global LV myocardial wall motion index (WMI) was calculated as the average wall motion score of all myocardial segments. The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI were also recorded.RESULTS: The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI was 7.1% after distal protection and 5.7% after conventional treatment (p = 0.17). WMI improved by 4.1% at 8 months in patients treated with distal protection compared to patients receiving conventional PCI (p < 0.01). In myocardium supplied by a culprit artery treated by distal protection regional LV function was 9-11% higher than myocardial regions treated conventionally ( p < 0.02).CONCLUSIONS: Routine use of distal protection during primary PCI is associated with a significant improvement in LV contractile function, with no detectable impact on intermediate term clinical outcome.

AB - BACKGROUND: Coronary intervention (PCI) may result in an increased infarct size. We evaluated the effect of distal protection during PCI for ST-segment elevation myocardial infarction (STEMI) on myocardial function.METHODS: Patients with STEMI were randomly referred within 12 h for PCI with (N = 312) or without distal protection (N = 314). Left ventricular (LV) contractile function was assessed with echocardiography 8 months after PCI. Global LV myocardial wall motion index (WMI) was calculated as the average wall motion score of all myocardial segments. The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI were also recorded.RESULTS: The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI was 7.1% after distal protection and 5.7% after conventional treatment (p = 0.17). WMI improved by 4.1% at 8 months in patients treated with distal protection compared to patients receiving conventional PCI (p < 0.01). In myocardium supplied by a culprit artery treated by distal protection regional LV function was 9-11% higher than myocardial regions treated conventionally ( p < 0.02).CONCLUSIONS: Routine use of distal protection during primary PCI is associated with a significant improvement in LV contractile function, with no detectable impact on intermediate term clinical outcome.

KW - Angioplasty, Balloon, Coronary/methods

KW - Humans

KW - Myocardial Contraction

KW - Myocardial Infarction/physiopathology

KW - Postoperative Complications/prevention & control

KW - Ventricular Function, Left

U2 - 10.1016/j.ijcard.2009.07.020

DO - 10.1016/j.ijcard.2009.07.020

M3 - Journal article

C2 - 19700209

SN - 0167-5273

VL - 146

SP - 395

EP - 398

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 3

ER -

Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial

Abstract

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