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Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment

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Mehlum, Camilla Slot ; Larsen, Stine Rosenkilde ; Kiss, Katalin ; Groentved, Aagot Moeller ; Kjaergaard, Thomas ; Möller, Sören ; Godballe, Christian. / Laryngeal precursor lesions : Interrater and intrarater reliability of histopathological assessment. I: The Laryngoscope. 2018 ; Bind 128, Nr. 10. s. 2375-2379.

Bibtex

@article{880a9944b1004b0391dd06b49346af81,
title = "Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment",
abstract = "OBJECTIVE: The World Health Organization classification (WHOC) 2017 of low-grade versus high-grade laryngeal dysplasia recently replaced the previous WHOC 2005 of mild, moderate, and severe dysplasia and carcinoma in situ. Our objectives were to compare the interrater agreement of the WHOC 2017 with that of the WHOC 2005 and to test the intra-rater agreement of the WHOC 2005.METHODS: Two expert head and neck pathologists rated 211 tissue samples that were initially diagnosed with laryngeal precursor lesions. The samples were rated twice according to the WHOC 2005 and once according to the WHOC 2017; estimates of interrater and intrarater agreements were calculated with kappa statistics.RESULTS: The crude intrarater agreements using the WHOC 2005 were 0.93 for rater 1 and 0.62 for rater 2. The corresponding unweighted kappa values were 0.90 (95% confidence interval [CI], 0.86-0.95) for rater 1 and 0.43 (95% CI, 0.35-0.54) for rater 2, whereas the standard linear weighted kappa values were 0.93 (95% CI, 0.90-0.97) for rater 1 and 0.60 (95% CI, 0.53-0.69) for rater 2. The crude interrater agreement for the WHOC 2005 was 0.57, with a corresponding unweighted kappa value 0.38 (95% CI, 0.31-0.48) and a standard linear weighted kappa value 0.52 (95% CI, 0.42-0.60). The crude interrater agreement for the WHOC 2017 was 0.83, with a corresponding unweighted kappa value 0.45 (95% CI, 0.31-0.59) and a standard linear weighted kappa value 0.46 (95% CI, 0.30-0.60).CONCLUSION: Our results indicate difficulties in providing reliable diagnosis of laryngeal precursor lesions, even with experienced head and neck pathologists and the application of a newly revised classification system.LEVEL OF EVIDENCE: 4. Laryngoscope, 128:2375-2379, 2018.",
keywords = "Biopsy, Carcinoma in Situ/pathology, Denmark, Humans, Hyperplasia, Laryngeal Neoplasms/pathology, Neoplasm Grading, Precancerous Conditions/pathology, Reproducibility of Results, World Health Organization",
author = "Mehlum, {Camilla Slot} and Larsen, {Stine Rosenkilde} and Katalin Kiss and Groentved, {Aagot Moeller} and Thomas Kjaergaard and S{\"o}ren M{\"o}ller and Christian Godballe",
note = "{\textcopyright} 2018 The American Laryngological, Rhinological and Otological Society, Inc.",
year = "2018",
month = oct,
doi = "10.1002/lary.27228",
language = "English",
volume = "128",
pages = "2375--2379",
journal = "The Laryngoscope",
issn = "0023-852X",
publisher = "JohnWiley & Sons, Inc",
number = "10",

}

RIS

TY - JOUR

T1 - Laryngeal precursor lesions

T2 - Interrater and intrarater reliability of histopathological assessment

AU - Mehlum, Camilla Slot

AU - Larsen, Stine Rosenkilde

AU - Kiss, Katalin

AU - Groentved, Aagot Moeller

AU - Kjaergaard, Thomas

AU - Möller, Sören

AU - Godballe, Christian

N1 - © 2018 The American Laryngological, Rhinological and Otological Society, Inc.

PY - 2018/10

Y1 - 2018/10

N2 - OBJECTIVE: The World Health Organization classification (WHOC) 2017 of low-grade versus high-grade laryngeal dysplasia recently replaced the previous WHOC 2005 of mild, moderate, and severe dysplasia and carcinoma in situ. Our objectives were to compare the interrater agreement of the WHOC 2017 with that of the WHOC 2005 and to test the intra-rater agreement of the WHOC 2005.METHODS: Two expert head and neck pathologists rated 211 tissue samples that were initially diagnosed with laryngeal precursor lesions. The samples were rated twice according to the WHOC 2005 and once according to the WHOC 2017; estimates of interrater and intrarater agreements were calculated with kappa statistics.RESULTS: The crude intrarater agreements using the WHOC 2005 were 0.93 for rater 1 and 0.62 for rater 2. The corresponding unweighted kappa values were 0.90 (95% confidence interval [CI], 0.86-0.95) for rater 1 and 0.43 (95% CI, 0.35-0.54) for rater 2, whereas the standard linear weighted kappa values were 0.93 (95% CI, 0.90-0.97) for rater 1 and 0.60 (95% CI, 0.53-0.69) for rater 2. The crude interrater agreement for the WHOC 2005 was 0.57, with a corresponding unweighted kappa value 0.38 (95% CI, 0.31-0.48) and a standard linear weighted kappa value 0.52 (95% CI, 0.42-0.60). The crude interrater agreement for the WHOC 2017 was 0.83, with a corresponding unweighted kappa value 0.45 (95% CI, 0.31-0.59) and a standard linear weighted kappa value 0.46 (95% CI, 0.30-0.60).CONCLUSION: Our results indicate difficulties in providing reliable diagnosis of laryngeal precursor lesions, even with experienced head and neck pathologists and the application of a newly revised classification system.LEVEL OF EVIDENCE: 4. Laryngoscope, 128:2375-2379, 2018.

AB - OBJECTIVE: The World Health Organization classification (WHOC) 2017 of low-grade versus high-grade laryngeal dysplasia recently replaced the previous WHOC 2005 of mild, moderate, and severe dysplasia and carcinoma in situ. Our objectives were to compare the interrater agreement of the WHOC 2017 with that of the WHOC 2005 and to test the intra-rater agreement of the WHOC 2005.METHODS: Two expert head and neck pathologists rated 211 tissue samples that were initially diagnosed with laryngeal precursor lesions. The samples were rated twice according to the WHOC 2005 and once according to the WHOC 2017; estimates of interrater and intrarater agreements were calculated with kappa statistics.RESULTS: The crude intrarater agreements using the WHOC 2005 were 0.93 for rater 1 and 0.62 for rater 2. The corresponding unweighted kappa values were 0.90 (95% confidence interval [CI], 0.86-0.95) for rater 1 and 0.43 (95% CI, 0.35-0.54) for rater 2, whereas the standard linear weighted kappa values were 0.93 (95% CI, 0.90-0.97) for rater 1 and 0.60 (95% CI, 0.53-0.69) for rater 2. The crude interrater agreement for the WHOC 2005 was 0.57, with a corresponding unweighted kappa value 0.38 (95% CI, 0.31-0.48) and a standard linear weighted kappa value 0.52 (95% CI, 0.42-0.60). The crude interrater agreement for the WHOC 2017 was 0.83, with a corresponding unweighted kappa value 0.45 (95% CI, 0.31-0.59) and a standard linear weighted kappa value 0.46 (95% CI, 0.30-0.60).CONCLUSION: Our results indicate difficulties in providing reliable diagnosis of laryngeal precursor lesions, even with experienced head and neck pathologists and the application of a newly revised classification system.LEVEL OF EVIDENCE: 4. Laryngoscope, 128:2375-2379, 2018.

KW - Biopsy

KW - Carcinoma in Situ/pathology

KW - Denmark

KW - Humans

KW - Hyperplasia

KW - Laryngeal Neoplasms/pathology

KW - Neoplasm Grading

KW - Precancerous Conditions/pathology

KW - Reproducibility of Results

KW - World Health Organization

U2 - 10.1002/lary.27228

DO - 10.1002/lary.27228

M3 - Journal article

C2 - 29729029

VL - 128

SP - 2375

EP - 2379

JO - The Laryngoscope

JF - The Laryngoscope

SN - 0023-852X

IS - 10

ER -

ID: 56701702