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Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

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Burgdorf, KS, Trabjerg, BB, Pedersen, MG, Nissen, J, Banasik, K, Pedersen, OB, Sørensen, E, Nielsen, KR, Larsen, MH, Erikstrup, C, Bruun-Rasmussen, P, Westergaard, D, Thørner, LW, Hjalgrim, H, Paarup, HM, Brunak, S, Pedersen, CB, Torrey, EF, Werge, T, Mortensen, PB, Yolken, RH & Ullum, H 2019, 'Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders' Brain, Behavior, and Immunity, bind 79, s. 152-158. https://doi.org/10.1016/j.bbi.2019.01.026

APA

CBE

Burgdorf KS, Trabjerg BB, Pedersen MG, Nissen J, Banasik K, Pedersen OB, Sørensen E, Nielsen KR, Larsen MH, Erikstrup C, Bruun-Rasmussen P, Westergaard D, Thørner LW, Hjalgrim H, Paarup HM, Brunak S, Pedersen CB, Torrey EF, Werge T, Mortensen PB, Yolken RH, Ullum H. 2019. Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain, Behavior, and Immunity. 79:152-158. https://doi.org/10.1016/j.bbi.2019.01.026

MLA

Vancouver

Author

Burgdorf, Kristoffer Sølvsten ; Trabjerg, Betina B ; Pedersen, Marianne Giørtz ; Nissen, Janna ; Banasik, Karina ; Pedersen, Ole Birger ; Sørensen, Erik ; Nielsen, Kaspar René ; Larsen, Margit Hørup ; Erikstrup, Christian ; Bruun-Rasmussen, Peter ; Westergaard, David ; Thørner, Lise Wegner ; Hjalgrim, Henrik ; Paarup, Helene Martina ; Brunak, Søren ; Pedersen, Carsten B ; Torrey, E Fuller ; Werge, Thomas ; Mortensen, Preben Bo ; Yolken, Robert H ; Ullum, Henrik. / Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. I: Brain, Behavior, and Immunity. 2019 ; Bind 79. s. 152-158.

Bibtex

@article{c27babdd98f64bce9d6f24595e8873ad,
title = "Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders",
abstract = "BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9{\%} of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95{\%} confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95{\%} CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95{\%} CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8{\%} of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95{\%} CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95{\%} CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95{\%} CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95{\%} CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95{\%} CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95{\%} CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.",
keywords = "Antibodies, Cytomegalovirus, Infection, Parasite, psychiatric disorders, Serology, Suicide, Toxoplasma gondii, Toxoplasmosis, Traffic accidents",
author = "Burgdorf, {Kristoffer S{\o}lvsten} and Trabjerg, {Betina B} and Pedersen, {Marianne Gi{\o}rtz} and Janna Nissen and Karina Banasik and Pedersen, {Ole Birger} and Erik S{\o}rensen and Nielsen, {Kaspar Ren{\'e}} and Larsen, {Margit H{\o}rup} and Christian Erikstrup and Peter Bruun-Rasmussen and David Westergaard and Th{\o}rner, {Lise Wegner} and Henrik Hjalgrim and Paarup, {Helene Martina} and S{\o}ren Brunak and Pedersen, {Carsten B} and Torrey, {E Fuller} and Thomas Werge and Mortensen, {Preben Bo} and Yolken, {Robert H} and Henrik Ullum",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = "7",
doi = "10.1016/j.bbi.2019.01.026",
language = "English",
volume = "79",
pages = "152--158",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

AU - Burgdorf, Kristoffer Sølvsten

AU - Trabjerg, Betina B

AU - Pedersen, Marianne Giørtz

AU - Nissen, Janna

AU - Banasik, Karina

AU - Pedersen, Ole Birger

AU - Sørensen, Erik

AU - Nielsen, Kaspar René

AU - Larsen, Margit Hørup

AU - Erikstrup, Christian

AU - Bruun-Rasmussen, Peter

AU - Westergaard, David

AU - Thørner, Lise Wegner

AU - Hjalgrim, Henrik

AU - Paarup, Helene Martina

AU - Brunak, Søren

AU - Pedersen, Carsten B

AU - Torrey, E Fuller

AU - Werge, Thomas

AU - Mortensen, Preben Bo

AU - Yolken, Robert H

AU - Ullum, Henrik

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

AB - BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N = 2591), have attempted or committed suicide (N = 655), or have had traffic accidents (N = 2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).RESULTS: T. gondii was detected in 25·9% of the population and was associated with schizophrenia (odds ratio [OR], 1·47; 95% confidence interval [CI], 1·03-2·09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2·78; 95% CI, 1·27-6·09). A very weak association between traffic accident and toxoplasmosis (OR, 1·11; 95% CI, 1·00-1·23, p = 0.054) was found. CMV was detected in 60·8% of the studied population and was associated with any psychiatric disorder (OR, 1·17; 95% CI, 1·06-1·29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1·27; 95% CI, 1·12-1·44), and with attempting or committing suicide (OR, 1·31; 95% CI, 1·10-1·56). Accounting for temporality, any psychiatric disorder (IRR, 1·37; 95% CI, 1·08-1·74) and mood disorders (IRR, 1·43; 95% CI, 1·01-2·04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1·06; 95% CI, 0·97-1·17) was found.CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

KW - Antibodies

KW - Cytomegalovirus

KW - Infection

KW - Parasite, psychiatric disorders

KW - Serology

KW - Suicide

KW - Toxoplasma gondii

KW - Toxoplasmosis

KW - Traffic accidents

UR - http://www.scopus.com/inward/record.url?scp=85061158198&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2019.01.026

DO - 10.1016/j.bbi.2019.01.026

M3 - Journal article

VL - 79

SP - 152

EP - 158

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

ER -

ID: 56560940